碳二亚胺插入磺酰亚胺：通过双原子糖精环扩展一步合成氮杂环庚三烯衍生物的路线。
Carbodiimide insertion into sulfonimides: one-step route to azepine derivatives via a two-atom saccharin ring expansion.
作者信息
Tan Davin, Friščić Tomislav
机构信息
Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W. H3A 0B8 Montreal, Canada.
出版信息
Chem Commun (Camb). 2017 Jan 16;53(5):901-904. doi: 10.1039/c6cc07331j. Epub 2016 Dec 23.
PMID:28008434
Abstract
A previously unknown insertion of carbodiimides into sulfonimides enables the first one-step, two-atom expansion of the saccharin 5-membered ring into a 7-membered benzo[1,2,4]thiadiazepine, and a two-atom chain extension of a non-cyclic sulfonimide. This reaction is enhanced by copper salts, which allow it to be conducted mechanochemically, in a solvent-free manner.
摘要
碳二亚胺插入磺酰亚胺这一前所未知的反应，首次实现了将糖精的五元环一步、双原子扩展为七元苯并[1,2,4]噻二氮杂卓环，并实现了非环状磺酰亚胺的双原子链延伸。铜盐可促进该反应，使其能够以无溶剂的机械化学方式进行。
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