支气管肺泡灌洗液中膜联蛋白A1水平升高作为肺癌的潜在诊断指标。
Increased level of annexin A1 in bronchoalveolar lavage fluid as a potential diagnostic indicator for lung cancer.
作者信息
Biaoxue Rong, Xiguang Cai, Hua Liu, Tian Fu, Wenlong Gao
机构信息
Department of Respiratory Medicine, First Affiliated Hospital, Xi'an Medical University, Xi'an - China.
Research Center of Prevention and Treatment of Respiratory Medicine, Xi'an - China.
出版信息
Int J Biol Markers. 2017 Mar 2;32(1):e132-e140. doi: 10.5301/jbm.5000243.
BACKGROUND
Annexin A1 has been implicated in various tumor types, but few studies have investigated its involvement in lung cancer. The purpose of this investigation was to quantify the annexin A1 level in bronchoalveolar lavage fluid (BALF) and analyze its usefulness in lung cancer diagnosis.
METHODS
Annexin A1 expression was measured by immunohistochemistry and enzyme immunoassay. The sensitivity and specificity of annexin A1 for distinguishing lung cancer were determined by receiver operator characteristic (ROC) curves.
RESULTS
Tumor tissues, BALF and serum of patients with lung cancer contained higher levels of annexin A1 than those of the control group of patients with benign lung diseases. Moreover, an increased level of BALF annexin A1 was closely correlated with lymphatic invasion and malignant progression of lung cancer. The sensitivity and specificity of BALF annexin A1 for distinguishing lung cancer were 94.2% and 90.2%, respectively.
CONCLUSIONS
Increased annexin A1 in BALF was correlated with lymphatic invasion and malignant progression of lung cancer, suggesting that it could be an indicator for discerning lung cancer and predicting outcome.
背景
膜联蛋白A1与多种肿瘤类型有关，但很少有研究探讨其在肺癌中的作用。本研究的目的是定量支气管肺泡灌洗液（BALF）中膜联蛋白A1的水平，并分析其在肺癌诊断中的应用价值。
方法
采用免疫组织化学和酶免疫测定法检测膜联蛋白A1的表达。通过受试者操作特征（ROC）曲线确定膜联蛋白A1鉴别肺癌的敏感性和特异性。
结果
肺癌患者的肿瘤组织、BALF和血清中膜联蛋白A1水平高于良性肺部疾病对照组患者。此外，BALF中膜联蛋白A1水平升高与肺癌的淋巴转移和恶性进展密切相关。BALF中膜联蛋白A1鉴别肺癌的敏感性和特异性分别为94.2%和90.2%。
结论
BALF中膜联蛋白A1升高与肺癌的淋巴转移和恶性进展相关，提示其可作为鉴别肺癌和预测预后的指标。
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