Yoon Hongju, Kim Yuna, Lee Yunmi
Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea.
Org Biomol Chem. 2017 Jan 25;15(4):790-795. doi: 10.1039/c6ob02606k.
A straightforward and efficient method for the synthesis of 1,2-diaryl-substituted enamines through the Cu-catalyzed electrophilic amination reaction of O-benzoyl hydroxylamines with vinylaluminum reagents generated in situ from the Ni-catalyzed hydroalumination of readily accessible internal aryl acetylenes is described. The amination is catalyzed by 1 mol% CuCl without any additive at ambient temperature to afford new versatile enamines in good yield (61-91%) with high selectivity (>98% E-enamine).