白细胞介素-6 -174G > C（rs1800795）基因多态性分布及其与类风湿性关节炎的关联：一项病例对照研究与荟萃分析
Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis.
作者信息
Dar Sajad Ahmad, Haque Shafiul, Mandal Raju Kumar, Singh Taru, Wahid Mohd, Jawed Arshad, Panda Aditya K, Akhter Naseem, Lohani Mohtashim, Areeshi Mohammed Yahya, Rai Gargi, Datt Shyama, Bhattacharya Sambit Nath, Ramachandran Vishnampettai Ganapathysubramanian, Das Shukla
机构信息
a Department of Microbiology , University College of Medical Sciences (University of Delhi) & GTB Hospital , Delhi , India.
b Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, University of Jazan , Jazan , Saudi Arabia.
出版信息
Autoimmunity. 2017 May;50(3):158-169. doi: 10.1080/08916934.2016.1261833. Epub 2016 Dec 23.
The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800-7.813, p < 0.001); dominant (OR = 2.800, 95% CI = 1.167-6.721, p = 0.021); and recessive (OR = 36.72, 95% CI = 2.004-672.7, p = 0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169-2.329, p = 0.004); homozygous (OR = 1.380, 95% CI = 0.906-2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001-2.428, p = 0.049); dominant (OR = 1.663, 95% CI = 1.078-2.567, p = 0.022); and recessive (OR = 1.366, 95% CI = 0.964-1.935, p = 0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361-10.190, p = 0.010); dominant (OR = 3.823, 95% CI = 1.320-11.074, p = 0.013); and recessive (OR = 4.357, 95% CI = 1.634-11.623, p = 0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.
白细胞介素-6（IL-6）-174G＞C（rs1800795）单核苷酸多态性（SNP）与类风湿性关节炎（RA）患病风险的关联是一个重要问题，因为文献中发表的报告相互矛盾且缺乏共识。我们对印度北部一家三级护理医院的34例RA患者进行了IL-6-174G＞C启动子多态性研究。我们还对先前发表的关于这种遗传关系的研究进行了荟萃分析，分析对象包括总体人群，以及分别按亚洲和白种人种族进行分析，以进一步阐明这种关联。总共分析了13项研究，包括本研究，涉及3291例RA病例和3812例对照。在这13项研究中，6项来自亚洲，6项来自白种人，1项来自混合人群。我们的病例对照研究表明，IL-6-174G＞C SNP与RA风险增加显著相关：等位基因（OR = 3.750，95% CI = 1.800 - 7.813，p ＜ 0.001）；显性（OR = 2.800，95% CI = 1.167 - 6.721，p = 0.021）；隐性（OR = 36.72，95% CI = 2.004 - 672.7，p = 0.015）。荟萃分析显示，在总体人群中，IL-6-174G＞C SNP与RA风险增加相关：等位基因（OR = 1.650，95% CI = 1.169 - 2.329，p = 0.004）；纯合子（OR = 1.380，95% CI = 0.906 - 2.101，p = 0.133）；杂合子（OR = 1.559，95% CI = 1.001 - 2.428，p = 0.049）；显性（OR = 1.663，95% CI = 1.078 - 2.567，p = 0.022）；隐性（OR = 1.366，95% CI = 0.964 - 1.935，p = 0.079）。亚组分析还表明，这种多态性与亚洲人群中RA风险增加相关：等位基因（OR = 3.724，95% CI = 1.361 - 10.190，p = 0.010）；显性（OR = 3.823，95% CI = 1.320 - 11.074，p =
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