Hao Xiaojuan, Zhao Huani, Zhu Linhui, Li Zhiteng, Yang Jing, Bai Qian
Rheumatology and Immunology Department, Third Ward, The Fifth Hospital of Xi'an City, Xi'an, 710082, China.
Rheumatology and Immunology Department, Second Ward, The Fifth Hospital of Xi'an City, Xi'an, 710082, China.
Heliyon. 2024 Oct 17;10(23):e39472. doi: 10.1016/j.heliyon.2024.e39472. eCollection 2024 Dec 15.
at present, there are inconsistent research findings regarding the precise relationship between IL-6 gene polymorphisms (GPMs) and rheumatoid arthritis (RA). This work employed meta-analysis (MA) methodology to systematically evaluate the correlation between IL-6 GPMs and susceptibility to RA.
this study comprehensively searched multiple databases from inception to March 31, 2024. The search utilized keywords including "IL-6," "Interleukin-6," "Cytokines," "Autoimmune diseases," "Arthritis," "rheumatoid arthritis," "Inflammation," "genetic polymorphism," and "genetic variation." Included studies focused on patients diagnosed with rheumatoid arthritis (RA), with healthy individuals or those without RA-related diseases as controls. The study designs encompassed cohort studies and case-control studies. Genetic frequency distributions of IL-6 gene rs1800795 (G-174C), rs1800796 (G-572C), and rs1800797 (G-597A) polymorphic sites were statistically analyzed. Quality of included studies was assessed. The preliminary assessment of literature heterogeneity was conducted. Quantitative assessment of heterogeneity results was performed using the I statistic in . Publication bias (PB) assessment was conducted.
the study included a total of 21 articles, comprising 9772 participants, with 4679 cases diagnosed with RA and 5093 individuals in the control (CT) group. The IL-6 gene allelic model (G C) exhibited a notable association with RA [OR = 0.66, 95%CI: 0.51-0.87, Z = 3.02, = 0.003]. In Southeast Asian populations, IL-6 gene rs1800795 (G-174C) genotype (CC) demonstrated a considerable correlation with RA [OR = 15.23, 95%CI: 3.53-65.67, = 0.00003]. IL-6 gene rs1800795 (G-174C) genotype (CG) was associated with RA [OR = 1.54, 95%CI: 1.10-2.17, Z = 2.48, = 0.01], with only the Asian population showing an observable correlation [OR = 6.55, 95%CI: 1.28-33.45, = 0.02]. Additionally, IL-6 rs1800795 (G-174C) genotype (GG) was associated with RA [OR = 0.66, 95%CI: 0.49-0.91, Z = 2.55, = 0.01], with notable associations observed in the Asian [OR = 0.17, 95%CI: 0.03-0.83, = 0.03] and mixed populations [OR = 1.29, 95%CI: 1.011.65, = 0.04]. No correlation was found between rs1800796 (G-572C) and rs1800797 (G-597A) GPMs and RA ( > 0.05).
IL-6 gene rs1800795 (G-174C) allelic model and genotypes (CC, CG, GG) were all associated with susceptibility to RA, with the G allele model being susceptible in Southeast Asian populations, and genotypes (CG and GG) being susceptible in Asian populations. However, there was neglectable correlation between rs1800796 (G-572C) and rs1800797 (G-597A) GPMs and susceptibility to RA.
目前，关于白细胞介素-6基因多态性（GPMs）与类风湿性关节炎（RA）之间的确切关系，研究结果并不一致。本研究采用荟萃分析（MA）方法，系统评估白细胞介素-6基因多态性与类风湿性关节炎易感性之间的相关性。
本研究全面检索了从数据库建立至2024年3月31日的多个数据库。检索使用的关键词包括“白细胞介素-6”“白细胞介素-6”“细胞因子”“自身免疫性疾病”“关节炎”“类风湿性关节炎”“炎症”“基因多态性”和“基因变异”。纳入的研究聚焦于被诊断为类风湿性关节炎（RA）的患者，以健康个体或无RA相关疾病的个体作为对照。研究设计包括队列研究和病例对照研究。对白细胞介素-6基因rs1800795（G-174C）、rs1800796（G-572C）和rs1800797（G-597A）多态性位点的基因频率分布进行了统计分析。评估了纳入研究的质量。对文献异质性进行了初步评估。使用I²统计量对异质性结果进行了定量评估。进行了发表偏倚（PB）评估。
该研究共纳入21篇文章，包括9772名参与者，其中4679例被诊断为RA，5093例在对照组（CT）。白细胞介素-6基因等位基因模型（G→C）与RA显著相关[比值比（OR）=0.66，95%置信区间（CI）：0.51 - 0.87，Z = 3.02，P = 0.003]。在东南亚人群中，白细胞介素-6基因rs1800795（G-174C）基因型（CC）与RA显著相关[OR = 15.23，95%CI：3.53 - 65.67，P = 0.00003]。白细胞介素-6基因rs1800795（G-174C）基因型（CG）与RA相关[OR = 1.54，95%CI：1.10 - 2.17，Z = 2.48，P = 0.01]，仅在亚洲人群中显示出明显相关性[OR = 6.55，95%CI：1.28 - 33.45，P = 0.02]。此外，白细胞介素-6 rs1800795（G-174C）基因型（GG）与RA相关[OR = 0.66，95%CI：0.49 - 0.91，Z = 2.55，P = 0.01]，在亚洲人群[OR = 0.17，95%CI：0.03 - 0.83，P = 0.03]和混合人群[OR = 1.29，95%CI：1.01 - 1.65，P =
