用于复发性非肌肉浸润性膀胱癌无创检测的蛋白质组验证
Validation of a protein panel for the noninvasive detection of recurrent non-muscle invasive bladder cancer.
作者信息
Gogalic Selma, Sauer Ursula, Doppler Sara, Heinzel Andreas, Perco Paul, Lukas Arno, Simpson Guy, Pandha Hardev, Horvath Andras, Preininger Claudia
机构信息
a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
b Emergentec Biodevelopment GmbH , Vienna , Austria.
出版信息
Biomarkers. 2017 Nov;22(7):674-681. doi: 10.1080/1354750X.2016.1276628. Epub 2017 Jan 19.
CONTEXT
About 50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease.
OBJECTIVE
To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC.
MATERIALS AND METHODS
Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis.
RESULTS
A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0.96.
DISCUSSION AND CONCLUSION
This biomarker panel represents a potential diagnostic tool for noninvasive diagnosis of recurrent NMIBC.
背景
约50 - 70%的非肌肉浸润性膀胱癌（NMIBC）患者会出现疾病复发。
目的
建立一个包含在多重微阵列（BCa芯片）中的蛋白质生物标志物面板以及用于诊断复发性NMIBC的分类器。
材料与方法
对45例患者的尿液样本进行检测。通过受试者工作特征（ROC）分析评估诊断性能。
结果
确定了一个多生物标志物面板（E - cadh、IL - 8、MMP - 9、EN2、VEGF、既往复发情况、卡介苗治疗情况及诊断时的分期），其曲线下面积为0.96。
讨论与结论
该生物标志物面板是用于复发性NMIBC无创诊断的潜在诊断工具。
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