Gogalic Selma, Sauer Ursula, Doppler Sara, Heinzel Andreas, Perco Paul, Lukas Arno, Simpson Guy, Pandha Hardev, Horvath Andras, Preininger Claudia
a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
b Emergentec Biodevelopment GmbH , Vienna , Austria.
Biomarkers. 2017 Nov;22(7):674-681. doi: 10.1080/1354750X.2016.1276628. Epub 2017 Jan 19.
About 50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease.
To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC.
Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis.
A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0.96.
This biomarker panel represents a potential diagnostic tool for noninvasive diagnosis of recurrent NMIBC.
约50 - 70%的非肌肉浸润性膀胱癌（NMIBC）患者会出现疾病复发。
建立一个包含在多重微阵列（BCa芯片）中的蛋白质生物标志物面板以及用于诊断复发性NMIBC的分类器。
对45例患者的尿液样本进行检测。通过受试者工作特征（ROC）分析评估诊断性能。
确定了一个多生物标志物面板（E - cadh、IL - 8、MMP - 9、EN2、VEGF、既往复发情况、卡介苗治疗情况及诊断时的分期），其曲线下面积为0.96。
该生物标志物面板是用于复发性NMIBC无创诊断的潜在诊断工具。
