Merighi Stefania, Borea Pier Andrea, Varani Katia, Gessi Stefania
Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy.
Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, Ferrara, Italy.
J Invest Dermatol. 2017 Jan;137(1):11-13. doi: 10.1016/j.jid.2016.08.001.
Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andrés et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A and A agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A and increased A.
