Medical Oncology Department, La Paz University Hospital, Autonoma University of Madrid, Paseo de la Castellana 261, 28046, Madrid, Spain.
Department of Medicine, Medical School, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Calle Arturo Duperier, 4, 28029 Madrid, Spain.
Crit Rev Oncol Hematol. 2017 Jan;109:9-19. doi: 10.1016/j.critrevonc.2016.11.007. Epub 2016 Nov 23.
Colorectal cancer (CRC) is characterized by alteration of critical pathways such TP53 inactivation, BRAF, PI3CA mutations, APC inactivation, KRAS, TGF-β, CTNNB mutations, disregulation of Epithelial to mesnechymal transition (EMT) genes, WNT signaling activation, MYC amplification, and others. Differences in these molecular events results in differences in phenotypic characteristics of CRC, that have been studied and classified by different models of molecular subtypes. It could have potential applications to prognosis, but also to therapeutical approaches of the CRC patients. We review and summarized the different molecular classifications and try to clarify their clinical and therapeutical relevance.
结直肠癌（CRC）的特征是关键途径的改变，如 TP53 失活、BRAF、PI3CA 突变、APC 失活、KRAS、TGF-β、CTNNB 突变、上皮-间充质转化（EMT）基因失调、WNT 信号激活、MYC 扩增等。这些分子事件的差异导致 CRC 的表型特征不同，这些特征已经通过不同的分子亚型模型进行了研究和分类。它可能对预后有潜在的应用，也可能对 CRC 患者的治疗方法有潜在的应用。我们综述并总结了不同的分子分类，并试图阐明其临床和治疗相关性。
