• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.

作者信息

Namasivayam Vigneshwaran, Lee Sang-Yong, Müller Christa E

机构信息

PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany.

PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry I, University of Bonn, Germany.

出版信息

Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):603-614. doi: 10.1016/j.bbagen.2016.12.019. Epub 2016 Dec 21.

DOI:10.1016/j.bbagen.2016.12.019
PMID:28011303
Abstract
摘要

相似文献

1
The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.多特异性胞外核苷酸酶NPP1:底物结合与水解的分子机制洞察
Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):603-614. doi: 10.1016/j.bbagen.2016.12.019. Epub 2016 Dec 21.
2
Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases.胞外ATP酶抑制剂ARL 67156对人和小鼠胞外核苷酸酶的特异性
Br J Pharmacol. 2007 Sep;152(1):141-50. doi: 10.1038/sj.bjp.0707361. Epub 2007 Jul 2.
3
Site-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.定点突变作图揭示了增强同功和限制碱性磷酸酶超家族磷酸二酯酶的混杂催化的相互作用。
Biochemistry. 2013 Dec 23;52(51):9167-76. doi: 10.1021/bi4010045. Epub 2013 Dec 11.
4
Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.二腺苷 5',5''-(硼酸化)多聚磷酸酯类似物作为选择性核苷酸焦磷酸酶/磷酸二酯酶抑制剂。
J Med Chem. 2010 Dec 23;53(24):8485-97. doi: 10.1021/jm100597c. Epub 2010 Nov 22.
5
Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke.核苷酸焦磷酸酶/磷酸二酯酶 4 和 1 介导的嘌呤信号代谢的分子基础及其在中风中的意义。
J Biol Chem. 2014 Feb 7;289(6):3294-306. doi: 10.1074/jbc.M113.505867. Epub 2013 Dec 12.
6
NO-induced activation of cyclic GMP-dependent pathway down regulates ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) protein in rat C6 glioma.一氧化氮诱导的环磷酸鸟苷依赖性途径激活可下调大鼠C6胶质瘤中的胞外核苷酸焦磷酸酶/磷酸二酯酶1(NPP1)蛋白。
Eur J Pharmacol. 2011 May 20;659(1):1-6. doi: 10.1016/j.ejphar.2011.03.004. Epub 2011 Mar 21.
7
A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities.一种高灵敏度的毛细管电泳方法,使用 p-硝基苯 5'-胸苷一磷酸作为核苷酸焦磷酸酶/磷酸二酯酶活性的监测底物。
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Dec 12;911:162-9. doi: 10.1016/j.jchromb.2012.10.044. Epub 2012 Nov 7.
8
Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system.对脑膜中外核苷酸焦磷酸酶磷酸二酯酶活性的生化分析表明,NPP1 同工酶参与中枢神经系统中二腺苷多磷酸的细胞外水解。
Neurochem Int. 2007 Mar;50(4):581-90. doi: 10.1016/j.neuint.2006.11.006. Epub 2006 Dec 21.
9
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.ECTO-核苷酸焦磷酸酶磷酸二酯酶 1 降解 cGAMP 的结构见解。
Nat Commun. 2018 Oct 24;9(1):4424. doi: 10.1038/s41467-018-06922-7.
10
NPP1 is responsible for potent extracellular ATP hydrolysis as NTPDase1 in primary cultured murine microglia.NPP1 作为原代培养的小鼠小胶质细胞中的 NTPDase1,负责强有力的细胞外 ATP 水解。
Purinergic Signal. 2018 Jun;14(2):157-166. doi: 10.1007/s11302-018-9601-z. Epub 2018 Mar 7.

引用本文的文献

1
Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations.通过基于结构的虚拟筛选和分子动力学模拟发现天然CdnP抑制剂。
Microbiol Spectr. 2025 Jun 3;13(6):e0325824. doi: 10.1128/spectrum.03258-24. Epub 2025 Apr 30.
2
Extracellular NAD levels are associated with CD203a expression on Th17 cells and predict long-term recurrence-free survival in hepatocellular carcinoma.细胞外烟酰胺腺嘌呤二核苷酸(NAD)水平与Th17细胞上CD203a的表达相关,并可预测肝细胞癌的长期无复发生存率。
J Cancer Res Clin Oncol. 2025 Mar 19;151(3):115. doi: 10.1007/s00432-025-06155-4.
3
Thymidine Phosphodiester Chemiluminescent Probe for Sensitive and Selective Detection of Ectonucleotide Pyrophosphatase 1.
用于灵敏且选择性检测胞外核苷酸焦磷酸酶1的胸苷磷酸二酯化学发光探针。
Bioconjug Chem. 2025 Feb 19;36(2):152-159. doi: 10.1021/acs.bioconjchem.4c00454. Epub 2025 Jan 9.
4
ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells.靶向ENPP1/CD203a的重链抗体揭示了其在人类免疫细胞上的细胞特异性表达。
Cell Mol Life Sci. 2024 Dec 18;82(1):6. doi: 10.1007/s00018-024-05539-y.
5
Naturally occurring quercetin and myricetin as potent inhibitors for human ectonucleotide pyrophosphatase/phosphodiesterase 1.天然存在的槲皮素和杨梅素是有效的人细胞外核苷酸焦磷酸酶/磷酸二酯酶 1 抑制剂。
Sci Rep. 2024 Jan 2;14(1):125. doi: 10.1038/s41598-023-50590-7.
6
Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.肝素是核苷酸外切焦磷酸酶/磷酸二酯酶-1(NPP1)的有效抑制剂-癌症免疫治疗的有希望的靶点。
Front Immunol. 2023 Aug 29;14:1173634. doi: 10.3389/fimmu.2023.1173634. eCollection 2023.
7
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy.蛋白激酶抑制剂塞利替尼抑制细胞外核苷酸酶 CD39——癌症免疫治疗的一个有希望的靶点。
J Immunother Cancer. 2022 Aug;10(8). doi: 10.1136/jitc-2022-004660.
8
Development of Novel Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Tumor Immunotherapy.新型核苷酸焦磷酸酶/磷酸二酯酶 1(ENPP1)抑制剂用于肿瘤免疫治疗的研究进展。
Int J Mol Sci. 2022 Jun 26;23(13):7104. doi: 10.3390/ijms23137104.
9
Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding.胆碱-O-硫酸酯酶结构研究揭示了配体结合的分子决定因素。
Acta Crystallogr D Struct Biol. 2022 May 1;78(Pt 5):669-682. doi: 10.1107/S2059798322003709. Epub 2022 Apr 26.
10
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.化学和生物分子策略在癌症免疫治疗中对 STING 通路的激活。
Chem Rev. 2022 Mar 23;122(6):5977-6039. doi: 10.1021/acs.chemrev.1c00750. Epub 2022 Feb 2.