肠型胃癌中雌激素和雄激素受体分布的性别差异
Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer.
作者信息
Jukic Zoran, Radulovic Petra, Stojković Ranko, Mijic August, Grah Josip, Kruslin Bozo, Ferencic Zeljko, Fucic Aleksandra
机构信息
General Hospital Nova Gradiska, Nova Gradiska, Croatia.
School of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia.
出版信息
Anticancer Res. 2017 Jan;37(1):197-202. doi: 10.21873/anticanres.11306.
BACKGROUND
Gender difference in survival of patients with gastric cancer is not well investigated. The aim of this study was to analyze the gender-related distribution of estrogen receptor alpha (ERα) and androgen receptor (AR) in the epithelium and stroma of intestinal-type gastric cancer.
MATERIALS AND METHODS
Immunohistochemical analysis was performed in 60 patients (42% females).
RESULTS
In gastric cancer patients, frequency of ERα-positive cells was lower in epithelium than in healthy individuals, but not significantly. In stroma and epithelium, AR-positive cells were absent from samples of women with T1 and T2 stage disease, while in men, their frequency was significantly increased in stroma of those with T3 and T4 stages and was significantly higher compared to women. AR-positive cells in stroma were fibroblasts, myofibroblasts and mast cells.
CONCLUSION
To our knowledge, this study is the first to show gender differences in the distribution and frequency of AR-positive cells in neoplastic stroma of gastric cancer.
背景
胃癌患者生存的性别差异尚未得到充分研究。本研究的目的是分析雌激素受体α（ERα）和雄激素受体（AR）在肠型胃癌上皮和基质中的性别相关分布。
材料与方法
对60例患者（42%为女性）进行免疫组织化学分析。
结果
在胃癌患者中，上皮中ERα阳性细胞的频率低于健康个体，但差异不显著。在基质和上皮中，T1和T2期疾病女性的样本中不存在AR阳性细胞，而在男性中，T3和T4期患者基质中的AR阳性细胞频率显著增加，且与女性相比显著更高。基质中的AR阳性细胞为成纤维细胞、肌成纤维细胞和肥大细胞。
结论
据我们所知，本研究首次表明胃癌肿瘤基质中AR阳性细胞的分布和频率存在性别差异。
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