Favino Marco, Pozzi Sonia, Pezzuto Simone, Prinzen Frits W, Auricchio Angelo, Krause Rolf
Center for Computational Medicine in Cardiology, Institute of Computational Science, Università della Svizzera Italiana, Via Giuseppe Buffi 13, Lugano CH-6900, Switzerland;
Center for Computational Medicine in Cardiology, Institute of Computational Science, Università della Svizzera Italiana, Via Giuseppe Buffi 13, Lugano CH-6900, Switzerland.
Europace. 2016 Dec;18(suppl 4):iv77-iv84. doi: 10.1093/europace/euw353.
Electrophysiological simulations may help to investigate causes and possible treatments of ventricular conduction disturbances. Most electrophysiological models do not take into account that the heart moves during the cardiac cycle. We used an electro-mechanical model to study the effect of mechanical deformation on the results of electrophysiological simulations.
Pseudo-electrocardiogram (ECG) were generated from the propagation of electrical signals in tissue slabs undergoing active mechanical deformation. We used the mono-domain equation for electrophysiology with the Bueno-Orovio ionic model and a fully incompressible Guccione-Costa hyperelastic law for the mechanics with the Nash-Panfilov model for the active force. We compared a purely electrophysiological approach (PE) with mono-directional (MD) and bi-directional (BD) electromechanical coupling strategies. The numerical experiments showed that BD and PE simulations led to different S- and T-waves. Mono-directional simulations generally approximated the BD ones, unless fibres were oriented along one short axis of the slab. When present, notching in the QRS-complex was larger in MD than in BD simulations.
Tissue deformation has to be taken into account when estimating the S- and T-wave of the ECG in electrophysiological simulations.
电生理模拟有助于研究心室传导障碍的病因及可能的治疗方法。大多数电生理模型未考虑心脏在心动周期中会运动这一因素。我们使用一个机电模型来研究机械变形对电生理模拟结果的影响。
通过在经历主动机械变形的组织切片中电信号的传播生成伪心电图（ECG）。我们使用带有布埃诺 - 奥罗维奥离子模型的单域电生理方程以及带有用于主动力的纳什 - 潘菲洛夫模型的完全不可压缩的古乔内 - 科斯塔超弹性定律来描述力学特性。我们将纯电生理方法（PE）与单向（MD）和双向（BD）机电耦合策略进行了比较。数值实验表明，BD和PE模拟产生了不同的S波和T波。单向模拟通常近似于BD模拟，除非纤维沿切片的一个短轴方向排列。当存在这种情况时，MD模拟中QRS复合波的切迹比BD模拟中的更大。
在电生理模拟中估计心电图的S波和T波时，必须考虑组织变形。
