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氯沙坦诱发咳嗽并伴有腹直肌鞘血肿的罕见病例:一名正在接受利伐沙班治疗的患者。

Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy.

作者信息

Talari Goutham, Talari Preetham, Sweigart Joseph, Ahmed Sadiq

机构信息

Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA.

Department of Internal Medicine-Nephrology, University of Kentucky Medical Center, Lexington, Kentucky, USA.

出版信息

BMJ Case Rep. 2016 Dec 23;2016:bcr2016217801. doi: 10.1136/bcr-2016-217801.

DOI:10.1136/bcr-2016-217801
PMID:28011889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5237777/
Abstract

Spontaneous rectus sheath haematomas and cough secondary to losartan are individually rare conditions. Abdominal wall haematomas present with abdominal pain and abdominal mass. Most patients are managed conservatively; Surgery or embolisation is indicated for shock, infection, rupture into the peritoneum or intractable pain. This is a man aged 65 years presented with dry cough and right-sided abdominal pain. He started losartan a few weeks prior to the onset of cough and had been on rivaroxaban for prior deep venous thrombosis. The right side of his abdomen was distended, bruised and tender. His haemoglobin dropped from 13.3to 9.5 g/dL. CT abdomen/pelvis showed a large 14.5×9.1×4.5 cm haematoma within the right lateral rectus muscle. His only risk factor for developing rectus sheath haematoma was cough in the setting of anticoagulation. Dry cough due to angiotensin receptor blockers is rare, but can have very serious consequences.

摘要

自发性腹直肌鞘血肿和氯沙坦引发的咳嗽各自都是罕见病症。腹壁血肿表现为腹痛和腹部肿块。大多数患者采用保守治疗;对于休克、感染、破入腹膜或顽固性疼痛则需进行手术或栓塞治疗。这是一名65岁男性,出现干咳和右侧腹痛。他在咳嗽发作前几周开始服用氯沙坦,此前因深静脉血栓一直在服用利伐沙班。他的右侧腹部膨隆、有瘀斑且压痛。他的血红蛋白从13.3降至9.5 g/dL。腹部/盆腔CT显示右侧腹直肌内有一个14.5×9.1×4.5 cm的大血肿。他发生腹直肌鞘血肿的唯一风险因素是在抗凝情况下咳嗽。血管紧张素受体阻滞剂引起的干咳很少见,但可能会产生非常严重的后果。

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本文引用的文献

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Spontaneous rectus sheath haematoma secondary to severe coughing in a patient with no other precipitating factors.一名无其他诱发因素的患者因剧烈咳嗽继发自发性腹直肌鞘血肿。
BMJ Case Rep. 2016 Feb 1;2016:bcr2016214362. doi: 10.1136/bcr-2016-214362.
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Rectus sheath hematoma in a single secondary care institution: a retrospective study.一家二级医疗机构的腹直肌鞘血肿:一项回顾性研究。
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Abdominal compartment syndrome--a fatal complication from a rectus sheath haematoma.腹腔间隔室综合征——一种来自腹直肌鞘血肿的致命并发症。
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Rectus sheath hematoma: review of 126 cases at a single institution.腹直肌鞘血肿:单机构126例病例回顾
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Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?对于因服用血管紧张素转换酶(ACE)抑制剂而出现咳嗽或血管性水肿的患者,能否使用血管紧张素II受体阻滞剂?
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Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough.氯沙坦、赖诺普利和美托拉宗在曾因血管紧张素转换酶抑制剂引发咳嗽的老年高血压患者中的双盲比较
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