Janghorbani Mohsen, Amini Masoud, Aminorroaya Ashraf
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Rev Diabet Stud. 2016 Summer-Fall;13(2-3):187-196. doi: 10.1900/RDS.2016.13.187. Epub 2016 Aug 10.
To evaluate the ability of low-level fasting high-density lipoprotein cholesterol (HDLC) to predict the incidence of type 2 diabetes (T2D) in an Iranian high-risk population.
Seven-year follow-up data (n = 1,775) in non-diabetic first-degree relatives (FDR) of consecutive patients with T2D aged 30-70 years were analyzed. The primary outcome was the diagnosis of T2D based on repeated oral glucose tolerance test (OGTT). We used Cox proportional hazard models to estimate the hazard ratio (HR) for the incidence of T2D across quartiles of HDLC, and plotted a receiver operating characteristic (ROC) curve to assess discrimination.
The highest quartile compared with the lowest quartile of HDLC was associated with T2D in age- and gender-adjusted models (HR: 0.83, 95% CI: 0.73-0.95). Further adjustment for fasting plasma glucose and cholesterol attenuated the association for T2D incidence (HR: 0.93, 95% CI: 0.80-1.08). The area under the ROC curve for HDLC was 54.1% (95% CI: 50.2-58.0).
HDLC level was a weak predictor of T2D in an Iranian high-risk population, independent of age and gender.
评估低水平空腹高密度脂蛋白胆固醇（HDLC）预测伊朗高危人群2型糖尿病（T2D）发病率的能力。
分析了30 - 70岁T2D连续患者的非糖尿病一级亲属（FDR）的七年随访数据（n = 1775）。主要结局是基于重复口服葡萄糖耐量试验（OGTT）诊断T2D。我们使用Cox比例风险模型估计HDLC四分位数中T2D发病率的风险比（HR），并绘制受试者工作特征（ROC）曲线以评估辨别力。
在年龄和性别调整模型中，HDLC最高四分位数与最低四分位数相比与T2D相关（HR：0.83，95%CI：0.73 - 0.95）。对空腹血糖和胆固醇进行进一步调整减弱了与T2D发病率的关联（HR：0.93，95%CI：0.80 - 1.08）。HDLC的ROC曲线下面积为54.1%（95%CI：50.2 - 58.0）。
在伊朗高危人群中，HDLC水平是T2D的弱预测指标，独立于年龄和性别。
