Wiens Kathryn, Williams Jeanne V A, Lavorato Dina H, Duffy Anne, Pringsheim Tamara M, Sajobi Tolulope T, Patten Scott B
Department of Community Health Sciences, University of Calgary, Canada.
Department of Community Health Sciences, University of Calgary, Canada.
J Affect Disord. 2017 Mar 1;210:22-26. doi: 10.1016/j.jad.2016.11.018. Epub 2016 Nov 23.
Major depressive disorder is a relatively common diagnosis with onset across the lifespan. There is a recent belief that major depressive episodes (MDE) are increasing in adolescence; however, it is not clear if this is truly an increase in prevalence or reflective of other causes such as change in diagnostic patterns. This study aimed to determine whether evidence supports an epidemic of MDE in Canadian adolescents.
Past year MDE prevalence estimates were derived from a series of nationally representative surveys. Random effects meta-regression and graphical analyses were used to evaluate trends. A post hoc analysis compared trends in MDE prevalence to trends in self-reported mood disorder diagnosis (made by a health professional). The sample was split into 9 birth cohorts to examine whether MDE prevalence increased in more recent cohorts.
Prevalence of MDE did not significantly change between 2000 and 2014 (β=0.001; p=0.532), and there was no modification of trends by sex or age. However, prevalence of self-reported mood disorder diagnosis by a health professional increased from 2003 to 2014 (β=0.001; p=0.024). There was no indication that MDE prevalence differed by birth cohort.
Limitations include reduced precision in subgroup analyses, lack of clinical judgement in the structured diagnostic interview, and inability to differentiate mild, moderate and severe episodes of depression.
These findings do not support an epidemic of MDE in adolescents, however as more individuals report diagnoses by a health professional, future policy may need to incorporate an increase in need of mental health services.
重度抑郁症是一种相对常见的诊断,发病贯穿一生。最近有人认为青少年中的重度抑郁发作(MDE)在增加;然而,目前尚不清楚这是否真的是患病率的增加,还是反映了其他原因,如诊断模式的变化。本研究旨在确定是否有证据支持加拿大青少年中存在MDE流行。
过去一年的MDE患病率估计值来自一系列具有全国代表性的调查。采用随机效应元回归和图形分析来评估趋势。事后分析将MDE患病率趋势与自我报告的情绪障碍诊断(由健康专业人员做出)趋势进行了比较。样本被分为9个出生队列,以检查MDE患病率在最近的队列中是否增加。
2000年至2014年间,MDE患病率没有显著变化(β=0.001;p=0.532),且趋势不受性别或年龄的影响。然而,健康专业人员自我报告的情绪障碍诊断患病率从2003年到2014年有所增加(β=0.001;p=0.024)。没有迹象表明MDE患病率因出生队列而异。
局限性包括亚组分析精度降低、结构化诊断访谈中缺乏临床判断,以及无法区分轻度、中度和重度抑郁发作。
这些发现不支持青少年中存在MDE流行,然而,随着越来越多的人报告由健康专业人员做出的诊断,未来的政策可能需要考虑到心理健康服务需求的增加。