Saraswati Nashi, Nayak Chetan, Sinha Sanjib, Nagappa Madhu, Thennarasu Kandavel, Taly Arun B
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), India.
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), India; Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Epilepsy Behav. 2017 Jan;66:34-38. doi: 10.1016/j.yebeh.2016.10.009. Epub 2016 Dec 22.
Patients with epilepsy commonly report excessive daytime sleepiness and daytime fatigue, which may be attributed to the direct effect of seizures, a side effect of antiepileptic drugs or a combination of the two. The aim of the study was to compare sleep profiles in patients with juvenile myoclonic epilepsy (JME) and symptomatic partial epilepsy (PE) in drug naïve and treated patients using standardized sleep questionnaires.
Three study groups: - 1) juvenile myoclonic epilepsy (N=40) [drug naïve (N=20); On sodium valproate (SVA) (N=20)]; 2) symptomatic partial epilepsy (N=40) [drug naïve (N=20); On carbamazepine (CBZ) (N=20)]; 3) healthy controls (N=40) completed 3 standardized sleep questionnaires - Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and NIMHANS Comprehensive Sleep Disorders Questionnaire. Scores were compared using t-test and Chi-squared tests (P≤0.005).
The mean PSQI scores as well as the proportion of subjects with abnormal PSQI scores were higher in patients with JME and PE compared to controls. Although the mean ESS scores were comparable between patients with epilepsy and controls, the percentage of patients with partial epilepsy having abnormal ESS scores was higher. No significant differences were present between drug naïve and treatment monotherapy groups. Excessive daytime somnolence was reported more often by patients with JME compared to patients with partial epilepsy and controls.
This study found that patients with epilepsy have a higher prevalence of poor sleep quality compared to controls. Moreover, a significantly higher percentage of patients with partial epilepsy had higher ESS scores compared to healthy controls. However, there was no difference between ESS and PSQI scores between drug naïve and treated patients with JME or PE.
Poor sleep quality is more prevalent in patients with epilepsy irrespective of the use of antiepileptic medications. Excessive daytime somnolence is more commonly seen in patients with partial epilepsy when compared to the general population.
癫痫患者常报告白天过度嗜睡和日间疲劳，这可能归因于癫痫发作的直接影响、抗癫痫药物的副作用或两者的结合。本研究的目的是使用标准化睡眠问卷比较初治和接受治疗的青少年肌阵挛性癫痫（JME）患者和症状性部分性癫痫（PE）患者的睡眠状况。
三个研究组：- 1）青少年肌阵挛性癫痫（N = 40）[初治（N = 20）；服用丙戊酸钠（SVA）（N = 20）]；2）症状性部分性癫痫（N = 40）[初治（N = 20）；服用卡马西平（CBZ）（N = 20）]；3）健康对照组（N = 40）完成了3份标准化睡眠问卷——爱泼沃斯思睡量表、匹兹堡睡眠质量指数和印度国家精神卫生和神经科学研究所综合睡眠障碍问卷。使用t检验和卡方检验比较得分（P≤0.005）。
与对照组相比，JME和PE患者的平均PSQI得分以及PSQI得分异常的受试者比例更高。虽然癫痫患者和对照组的平均ESS得分相当，但部分性癫痫患者ESS得分异常的百分比更高。初治组和治疗单药组之间无显著差异。与部分性癫痫患者和对照组相比，JME患者报告白天过度嗜睡的情况更常见。
本研究发现，与对照组相比，癫痫患者睡眠质量差的患病率更高。此外，与健康对照组相比，部分性癫痫患者ESS得分较高的百分比显著更高。然而，初治和接受治疗的JME或PE患者之间的ESS和PSQI得分没有差异。
无论是否使用抗癫痫药物，癫痫患者睡眠质量差的情况更为普遍。与普通人群相比，部分性癫痫患者白天过度嗜睡更为常见。
