Bigos S T, MacLean J, Butler B
Division of Endocrinology, Maine Medical Center, Portland, Maine 04102.
J Biolumin Chemilumin. 1989 Jul;4(1):627-34. doi: 10.1002/bio.1170040183.
A study of 239 patients compared free thyroxine (FT4) measurements made by equilibrium dialysis (ED) with measurements made using the Magic Lite FT4 chemiluminescence (CI) immunoassay (Ciba Corning Immunodiagnostics). Patient groups: 41 normals; 27 hyperthyroid; 29 hypothyroid; 37 sick euthyroid; 10 chronic renal failure (CRF) and 25 pregnant patients; 13 oestrogen; 10 heparin; 12 salicylate; and 9 dilantin-treated patients; 3 lipaemic; 5 haemolysed; 6 hyperbilirubinaemic patients; 6 low thyroid binding protein (TBP) and 6 high TBP level patients. The two assays gave comparable results in most groups. Both assays tended to give elevated values in heparinized patients but FT4-ED results were more obviously affected. Pregnant patients and women on oral oestrogen had higher mean values with FT4-ED. In both assays the sick euthyroid and CRF patients had mean FT4 values similar to healthy euthyroid patients; the range of values in sick euthyroid and CRF patients was similar in both assays but wider than in healthy euthyroid patients. A supplemental study of 81 unselected acutely ill patients using FT4-Cl alone confirmed the wider range of values to be anticipated in sick euthyroid patients.
一项针对239名患者的研究，比较了采用平衡透析法（ED）测定的游离甲状腺素（FT4）与使用Magic Lite FT4化学发光免疫分析法（CI）（拜耳康宁免疫诊断公司）测定的结果。患者分组如下：41名正常人；27名甲状腺功能亢进患者；29名甲状腺功能减退患者；37名甲状腺功能正常的患病患者；10名慢性肾衰竭（CRF）患者和25名孕妇；13名使用雌激素的患者；10名使用肝素的患者；12名使用水杨酸盐的患者；9名接受苯妥英治疗的患者；3名脂血患者；5名溶血患者；6名高胆红素血症患者；6名甲状腺结合蛋白（TBP）水平低的患者和6名TBP水平高的患者。在大多数组中，两种检测方法得出的结果相当。在使用肝素的患者中，两种检测方法得出的值往往都会升高，但FT4-ED的结果受影响更明显。孕妇和口服雌激素的女性使用FT4-ED时平均值更高。在两种检测方法中，甲状腺功能正常的患病患者和CRF患者的FT4平均值与甲状腺功能正常的健康患者相似；甲状腺功能正常的患病患者和CRF患者的数值范围在两种检测方法中相似，但比甲状腺功能正常的健康患者更宽。一项针对81名未经挑选的急性病患者仅使用FT4-Cl的补充研究证实，甲状腺功能正常的患病患者预期值范围更宽。
