家族性弥漫性肺骨化：一种可能的遗传性疾病。

Familial diffuse pulmonary ossification: A possible genetic disorder.

作者信息

Kinoshita Yoshiaki, Mizuguchi Ichiko, Hidaka Kouko, Ishii Hiroshi, Watanabe Kentaro

机构信息

Department of Respiratory Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Division of Respiratory Medicine, Department of Internal Medicine, National Hospital Organization, Kokura Medical Center, 10-1 Harugaoka, Kokura-minamiku, Kitakyushu 802-8533, Japan.

出版信息

Respir Investig. 2017 Jan;55(1):79-82. doi: 10.1016/j.resinv.2016.10.005. Epub 2016 Nov 17.

DOI:10.1016/j.resinv.2016.10.005

PMID:28012500

Abstract

Diffuse pulmonary ossification (DPO) is an uncommon disease that is characterized by the widespread formation of ectopic bone in the lungs. Herein, we describe two familial cases of DPO. The patients were a 47-year-old woman and her 76-year-old father. Both patients had a history of recurrent cough, and their chest images showed multiple nodules with ossification. No underlying diseases that might have caused DPO were evident; however, the female patient also had congenital finger hypoplasia and deformity. The present cases indicate the possibility that DPO might be partly associated with genetic disorders.

摘要

弥漫性肺骨化（DPO）是一种罕见疾病，其特征是肺部广泛形成异位骨。在此，我们描述两例DPO家族病例。患者为一名47岁女性及其76岁父亲。两名患者均有反复咳嗽病史，胸部影像显示多个伴有骨化的结节。未发现可能导致DPO的潜在疾病；然而，女性患者还患有先天性手指发育不全和畸形。目前的病例表明DPO可能部分与遗传疾病有关。