Kashem Mohammed Abul, Lee Aven, Pow David V, Šerý Omar, Balcar Vladimir J
Laboratory of Neurochemistry, Bosch Institute and Discipline of Anatomy and Histology, School of Medical Sciences, Sydney Medical School, The University of Sydney, 2006 Sydney, NSW, Australia.
UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.
Med Hypotheses. 2017 Jan;98:57-59. doi: 10.1016/j.mehy.2016.11.015. Epub 2016 Nov 24.
It has been known that a preconception paternal alcoholism impacts adversely on the offspring but the mechanism of the effect is uncertain. Several findings suggest that there are signalling systems in testis that are analogous to those known to be altered by alcoholism in brain. We propose that chronic alcohol affects these systems in a manner similar to that in brain. Specifically, we hypothesise that excessive alcohol may disturb glutamatergic-like signalling in testis by increasing expression of the glutamate transporter GLAST (EAAT1). We discuss ways how to test the hypothesis as well as potential significance of some of the tests as tools in the diagnostics of chronic alcoholism.
已知孕前父亲酗酒会对后代产生不利影响，但这种影响的机制尚不确定。多项研究结果表明，睾丸中存在一些信号系统，类似于已知在大脑中因酗酒而改变的信号系统。我们认为，慢性酒精以类似于在大脑中的方式影响这些系统。具体而言，我们假设过量酒精可能通过增加谷氨酸转运体GLAST（EAAT1）的表达来干扰睾丸中的类谷氨酸能信号。我们讨论了如何检验这一假设，以及其中一些检验作为慢性酒精中毒诊断工具的潜在意义。
