Department of Respiratory Medicine, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan, China.
Department of Thoracic Surgery, Ji'nan Central Hospital Affiliated to Shandong University, No. 105 Jiefang Road, Ji'nan 250013, Shandong, China.
Biomed Pharmacother. 2017 Feb;86:466-474. doi: 10.1016/j.biopha.2016.12.003. Epub 2016 Dec 23.
MicroRNA-590 (miR-590) shows oncogenic functions in various tumor types, but little is known about biological functions of miR-590 in lung adenocarcinoma. In this study, we observe that miR-590 is not only overexpressed in lung adenocarcinoma tissues and metastatic lymph nodes, but also significantly increased in lung adenocarcinoma cell lines. Moreover, gain-of-function and loss-of-function studies show miR-590 serve as a tumor suppressor regulating lung adenocarcinoma cells migration and invasion. Furthermore, OLFM4 is proved to as a functional target for miR-590 to regulate lung adenocarcinoma cells migration and invasion. In conclusion, miR-590 regulates lung adenocarcinoma metastasis through directly modulating functional target OLFM4.
微小 RNA-590（miR-590）在各种肿瘤类型中表现出致癌功能，但关于 miR-590 在肺腺癌中的生物学功能知之甚少。在这项研究中，我们观察到 miR-590 不仅在肺腺癌组织和转移淋巴结中过度表达，而且在肺腺癌细胞系中也显著增加。此外，功能获得和功能丧失研究表明，miR-590 作为一种肿瘤抑制因子，调节肺腺癌细胞的迁移和侵袭。此外，OLFM4 被证明是 miR-590 调节肺腺癌细胞迁移和侵袭的功能靶标。总之，miR-590 通过直接调节功能靶标 OLFM4 来调节肺腺癌的转移。
