Chiba K, Shirota H, Katayama K, Yamatsu I
Eisai Research Laboratories, Eisai Co. Ltd., Ibaraki, Japan.
Agents Actions. 1989 Jun;27(3-4):359-60. doi: 10.1007/BF01972822.
The in vivo production of lymphocyte activating factor (LAF) activity was investigated in the exudate of the rat air-pouch inflammation model. An inflammatory reaction was induced by lipopolysaccharide (LPS) injection into the air-pouch, and the time course of LAF activity in the exudate was investigated. LAF activity in the exudate reached a peak by 6 h, and rapidly decreased at 10 to 48 h after the LPS injection. Dexamethasone revealed strong inhibitory action on LAF activity and granuloma formation. On the other hand, indomethacin could not inhibit either of the phenomena. In conclusion, LAF (IL-1) is rapidly produced after the onset of inflammation and may participate in the subsequent granuloma formation.
在大鼠气囊炎症模型的渗出液中研究了淋巴细胞激活因子（LAF）活性的体内产生情况。通过向气囊内注射脂多糖（LPS）诱导炎症反应，并研究渗出液中LAF活性的时间进程。渗出液中的LAF活性在6小时时达到峰值，并在LPS注射后10至48小时迅速下降。地塞米松对LAF活性和肉芽肿形成显示出强烈的抑制作用。另一方面，吲哚美辛不能抑制这两种现象。总之，LAF（白细胞介素-1）在炎症发作后迅速产生，并可能参与随后的肉芽肿形成。
