Little J W, Hall W J, Douglas R G
Ann N Y Acad Sci. 1977 Mar 4;284:106-17. doi: 10.1111/j.1749-6632.1977.tb21941.x.
Previous studies have demonstrated alterations in gas exchange and pulmonary mechanics in presumed and documented viral upper respiratory infections. In our laboratory, using sensitive and noninvasive testing, we have demonstrated significant and prolonged alterations of pulmonary mechanics in uncomplicated natural influenza A infection, which implicate increased resistance in small airways as the cause of dysfunction. Amantadine administration in established influenza A infection has been associated with an accelerated improvement of clinical illness and pulmonary physiologic dysfunction. Preliminary study suggests that this is due to neither cholinergic blockade nor bronchodilation.
先前的研究已经证实在假定的和已确诊的病毒性上呼吸道感染中，气体交换和肺力学存在改变。在我们实验室，通过使用灵敏且无创的检测方法，我们已经证实在无并发症的自然甲型流感感染中，肺力学存在显著且持续时间较长的改变，这表明小气道阻力增加是功能障碍的原因。在已确诊的甲型流感感染中使用金刚烷胺与临床疾病和肺生理功能障碍的加速改善有关。初步研究表明，这既不是由于胆碱能阻滞也不是由于支气管扩张所致。
