Jurgensen C H, Wolberg G, Zimmerman T P
Wellcome Research Laboratories, Research Triangle Park, NC 27709.
Agents Actions. 1989 Jun;27(3-4):398-400. doi: 10.1007/BF01972833.
Treatment of cultured human umbilical vein endothelial cells (HUVE) with tumor necrosis factor alpha (TNF-alpha) increases their capacity to adhere human neutrophils. We have found that 3-deazaadenosine (c3Ado), when added in conjunction with TNF-alpha, inhibited this increase in neutrophil adherence. This activity of c3Ado was potentiated by the addition of L-homocysteine thiolactone (Hcy). The ability of c3Ado to inhibit neutrophil adherence to HUVE may contribute to the anti-inflammatory activity of this nucleoside analogue.
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