Santos Ana M, Peña Paola, Avila Mabel, Briceño Ignacio, Jaramillo Carlos, Vargas-Alarcon Gilberto, Rueda Juan C, Saldarriaga Eugenia-Lucia, Angarita Jose-Ignacio, Martinez-Rodriguez Nancy, Londono John
Department of Rheumatology, Universidad de La Sabana-Hospital Militar Central, Km 7, Autopista Norte de Bogota, Chia, Colombia.
Faculty of Medicine, Grupo Genética Humana, Universidad de La Sabana, Chia, Colombia.
Clin Rheumatol. 2017 Apr;36(4):953-958. doi: 10.1007/s10067-016-3516-2. Epub 2016 Dec 24.
There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR. Of the 189 studied patients, 35 were reactive arthritis (ReA), 87 were ankylosing spondylitis (AS), and 67 undifferentiated SpA (uSpA). According to the Assessment of Spondyloarthritis International Society (ASAS) criteria, 167 were axial SpA (axSpA) and 171 were peripheral SpA (pSpA). 63.8% were men, with a mean age of 35.9 ± 12.7 years. 40.7% (77/189) of patients were HLA-B27 positive of which 52.9% had AS and 42.5% axSpA. 23.2% (44/189) of patients were HLA-B15 positive: 23.8% were uSpA, 12.57% were axSpA, and 11.7% were pSpA. In addition, HLA-DRB101 was associated with AS (58.6%) and axSpA (42.5%). Also, HLA-DRB104 was present in 62 patients with AS (71.2%) and in 26 with axSpA (15.5%). In this population, we found a strong association between the presence of HLA-B27 and the diagnosis of axSpA and AS, but the HLA-B15 is also significantly associated with all subtypes of the disease, predominantly with pSpA. Additionally, HLA-DR1 and DR4 were associated in a cohort of patients with SpA from Colombia.
有大量证据表明，非B27主要组织相容性复合体（MHC）基因与脊柱关节炎（SpA）相关。对墨西哥和突尼斯人群的研究表明SpA与人类白细胞抗原（HLA）B15有关联。本研究的目的是评估一组诊断为SpA的哥伦比亚患者中HLA - A、B和DR抗原的关联性。本研究共纳入189例患者和100名健康受试者。所有受试者均对HLA等位基因A、B和DR进行了全面鉴定。在189例研究患者中，35例为反应性关节炎（ReA），87例为强直性脊柱炎（AS），67例为未分化脊柱关节炎（uSpA）。根据国际脊柱关节炎评估协会（ASAS）标准，167例为轴向SpA（axSpA），171例为外周SpA（pSpA）。63.8%为男性，平均年龄35.9±12.7岁。40.7%（77/189）的患者HLA - B27呈阳性，其中52.9%患有AS，42.5%患有axSpA。23.2%（44/189）的患者HLA - B15呈阳性：23.8%为uSpA，12.57%为axSpA，11.7%为pSpA。此外，HLA - DRB101与AS（58.6%）和axSpA（42.5%）相关。同时，HLA - DRB104在62例AS患者（71.2%）和26例axSpA患者（15.5%）中出现。在该人群中，我们发现HLA - B27的存在与axSpA和AS的诊断之间存在强关联，但HLA - B15也与该疾病的所有亚型显著相关，主要与pSpA相关。此外，在一组来自哥伦比亚的SpA患者中，HLA - DR1和DR4存在关联。
