Alarcón Del Agua I, Socas-Macias M, Busetto L, Torres-Garcia A, Barranco-Moreno A, Garcia de Luna P P, Morales-Conde S
Innovation and Minimal Invasive Surgery Unit, Virgen del Rocío, Hospital Virgen del Rocio, Avda Manuel Siurot, S/N, 41010, Sevilla, Spain.
Department of Medicine - University of Padova, Center for the Study and the Integrated Management of Obesity, Clinica Medica 3 - Padova University Hospital, Via Giustiniani 2, 35128, Padova, Italy.
Obes Surg. 2017 Jun;27(6):1573-1580. doi: 10.1007/s11695-016-2495-3.
To determine possible preoperative predictors for obtaining clinically meaningful weight loss with gastric electrical stimulation (GES) using the "Three-Factor Eating Questionnaire" (TFEQ) as well as epidemiological data.
Ninety-seven obese participants in a prospective multicenter randomized study conducted in nine European centers were implanted laparoscopically with the abiliti® closed-loop GES system (CLGES). Five clinical variables and three preoperative TFEQ factor scores (F1-cognitive-restraint, F2-disinhibition, and F3-hunger) were analyzed in order to determine predictors of weight loss success defined as excess weight loss (EWL) > 30% and failure defined as EWL < 20% at 12 months post-surgery.
The mean 12-month %EWL with CLGES was 35.1 ± 19.7%, with a success rate of 52% and a failure rate of 19%. Significant predictors of success were body mass index (BMI) < 40 kg/m and age ≥ 50 years, increasing probability of success by 22 and 29%, respectively. A low F1-cognitive-restraint score was a significant predictor of failure (p = 0.004). The best predictive model for success included F1-cognitive-restraint, F2-disinhibition, BMI < 40, and age ≥ 50 (p = 0.002).
This retrospective analysis has shown that age, preoperative BMI, and F1-cognitive-restraint and F2-disinhibition scores from a preoperatively administered TFEQ are predictive of weight loss outcomes with CLGES and may be used for patient selection.
ClinicalTrials.gov Identifier: NCT01448785.
使用“三因素饮食问卷”（TFEQ）以及流行病学数据来确定通过胃电刺激（GES）实现具有临床意义的体重减轻的术前可能预测因素。
在欧洲九个中心进行的一项前瞻性多中心随机研究中，97名肥胖参与者通过腹腔镜植入abiliti®闭环GES系统（CLGES）。分析了五个临床变量和三个术前TFEQ因子得分（F1-认知抑制、F2-去抑制和F3-饥饿），以确定体重减轻成功的预测因素，定义为术后12个月超重减轻（EWL）>30%，失败定义为EWL<20%。
CLGES术后12个月的平均EWL百分比为35.1±19.7%，成功率为52%，失败率为19%。成功的显著预测因素是体重指数（BMI）<40kg/m²和年龄≥50岁，成功概率分别增加22%和29%。低F1-认知抑制得分是失败的显著预测因素（p=0.004）。成功的最佳预测模型包括F1-认知抑制、F2-去抑制、BMI<40和年龄≥50（p=0.002）。
这项回顾性分析表明，年龄、术前BMI以及术前TFEQ的F1-认知抑制和F2-去抑制得分可预测CLGES的体重减轻结果，可用于患者选择。
ClinicalTrials.gov标识符：NCT01448785。
