Suzuki R, Yoshino H, Nakayama M
Nippon Ganka Gakkai Zasshi. 1989 May;93(5):529-32.
Effects of prostaglandins and/or indomethacin on the cooling induced contraction of the bovine iris sphincter muscle were studied in vitro. Cooling of the bathing solution contracted the bovine iris sphincter and the muscle became sensitive to carbachol. Lowering the temperature elevated the muscle tone, while with pretreatment of indomethacin, the elevation was markedly inhibited. Further application of prostaglandins (PGs) such as 10(-8)-3 X 10(-8) M PGE2 reproduced the response induced by low temperature. Effects of cimetidine, methysergide and naloxone were also studied. Whether PGs are exogenously applied or endogenously produced, PGs are responsible for the induction of such responses.
在体外研究了前列腺素和/或吲哚美辛对牛虹膜括约肌冷却诱导收缩的影响。浴液冷却使牛虹膜括约肌收缩，且该肌肉对卡巴胆碱变得敏感。降低温度会提高肌张力，而用吲哚美辛预处理后，这种升高会受到明显抑制。进一步应用前列腺素（PGs），如10^(-8)-3×10^(-8) M的前列腺素E2，可重现低温诱导的反应。还研究了西咪替丁、甲基麦角新碱和纳洛酮的作用。无论PGs是外源性应用还是内源性产生，PGs都参与了此类反应的诱导。
