Dal Cin P, Gaeta J, Huben R, Li F P, Prout G R, Sandberg A A
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Am J Clin Pathol. 1989 Oct;92(4):408-14. doi: 10.1093/ajcp/92.4.408.
The authors examined three cortical tumors (adenomas) of the kidney and found a consistent chromosome pattern. A combination of chromosome abnormalities (+7, +7, +17, -Y) was shared by these tumors. In contrast, none of them showed alterations of chromosome 3p and 5q, the most common changes in renal cell carcinomas. The chromosome abnormalities in these patients may define a subgroup of renal tumors, so-called adenomas, that cannot be distinguished easily from adenocarcinomas in histopathologic examination.
作者检查了三个肾皮质肿瘤（腺瘤），发现了一致的染色体模式。这些肿瘤共有一组染色体异常（+7、+7、+17、-Y）。相比之下，它们均未显示出肾细胞癌中最常见的3p和5q染色体改变。这些患者的染色体异常可能定义了一个肾肿瘤亚组，即所谓的腺瘤，在组织病理学检查中难以与腺癌区分开来。
