较低的体重指数与帕金森病患者的体位性低血压有关。
Lower body mass index is associated with orthostatic hypotension in Parkinson's disease.
作者信息
Nakamura Tomohiko, Suzuki Masashi, Ueda Miki, Hirayama Masaaki, Katsuno Masahisa
机构信息
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Department of Laboratory Medicine, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
出版信息
J Neurol Sci. 2017 Jan 15;372:14-18. doi: 10.1016/j.jns.2016.11.027. Epub 2016 Nov 15.
INTRODUCTION
Lower body mass index (BMI) is associated with orthostatic hypotension (OH) in the general population, especially in the elderly; however, no studies have addressed this issue in Parkinson's disease (PD).
METHODS
We investigated the results of the head-up tilt test and BMI of patients with PD, and evaluated whether BMI is related to orthostatic systolic blood pressure (SBP) change during the head-up tilt test. PD patients were divided into male and female groups, and further divided into middle-aged (age<65years) and elderly (age≥65years) subgroups in each sex.
RESULTS
OH was observed in 13 of 64 male and 12 of 75 female patients with PD. BMI was lower in patients with OH than in those without, in both men and women. In the elderly group, a significant correlation between BMI and orthostatic SBP change was found (men, r=0.47, p=0.006; women, r=0.43, p=0.005), and a BMI below mean-0.5 standard deviation increased OH odds (men: BMI<20.5; odds ratio, 6.79; 95% CI, 1.06-43.36; women: BMI<18.5; odds ratio, 5.11; 95% CI, 1.05-24.96).
CONCLUSION
Lower BMI is a predisposing factor of OH in elderly patients with PD.
引言
在普通人群中，尤其是老年人，较低的体重指数（BMI）与直立性低血压（OH）相关；然而，尚无研究探讨帕金森病（PD）患者中的这一问题。
方法
我们调查了PD患者的直立倾斜试验结果和BMI，并评估BMI是否与直立倾斜试验期间的直立收缩压（SBP）变化相关。PD患者分为男性和女性组，每组再按性别分为中年（年龄<65岁）和老年（年龄≥65岁）亚组。
结果
64例男性PD患者中有13例、75例女性PD患者中有12例出现OH。无论男性还是女性，OH患者的BMI均低于无OH患者。在老年组中，发现BMI与直立SBP变化之间存在显著相关性（男性，r=0.47，p=0.006；女性，r=0.43，p=0.005），BMI低于均值减0.5个标准差会增加OH的发生几率（男性：BMI<20.5；比值比，6.79；95%CI，1.06-43.36；女性：BMI<18.5；比值比，5.11；95%CI，1.05-24.96）。
结论
较低的BMI是老年PD患者发生OH的一个易感因素。
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