Camerota F, Celletti C, Di Sipio E, De Fino C, Simbolotti C, Germanotta M, Mirabella M, Padua L, Nociti V
Umberto I Hospital and Sapienza University, Rome, Italy.
Fondazione Don Gnocchi-ONLUS, Milan, Italy.
J Neurol Sci. 2017 Jan 15;372:33-39. doi: 10.1016/j.jns.2016.11.025. Epub 2016 Nov 15.
Gait impairment is one of the most frequent and life-altering consequences of Multiple sclerosis (MS), frequently associated with lower limb spasticity. Focal muscle vibration (fMV) is a technique that applies a vibratory stimulus to a specific muscle or its tendon, reducing spasticity. The aim of our study is to evaluate the efficacy of fMV in ameliorating gait impairment in MS patients with severe lower limb spasticity, measured by Gait Analysis (GA) and objective and patient-oriented scales scores. Fourteen patients affected by Secondary Progressive MS (SPMS) with a lower limb spasticity with a low or no response to antispastic drugs, received repetitive fMV (r-fMV) over the quadriceps and the lumbar paraspinal muscles. The effect of r-fMV on gait was measured by a GA evaluation and objective and patient-oriented scales scores, performed before r-fMV (T0), and 1week (T1) and 1month (T2) after the last session of r-fMV. After the r-fMV the most of spatio-temporal parameters calculated by GA were improved. Moreover, clinical evaluation related results showed an improvement of SM patients' quality of life. In conclusion, r-fMV improves gait function in MS patients affected by severe spasticity of lower limb, non-responsive to common oral antispastic drugs.
步态障碍是多发性硬化症（MS）最常见且改变生活的后果之一，常与下肢痉挛有关。局部肌肉振动（fMV）是一种向特定肌肉或其肌腱施加振动刺激以减轻痉挛的技术。我们研究的目的是通过步态分析（GA）以及客观和以患者为导向的量表评分，评估fMV改善重度下肢痉挛的MS患者步态障碍的疗效。14例患有继发性进展型MS（SPMS）且下肢痉挛对抗痉挛药物反应低或无反应的患者，接受了股四头肌和腰部椎旁肌的重复fMV（r-fMV）治疗。通过GA评估以及客观和以患者为导向的量表评分来测量r-fMV对步态的影响，在r-fMV治疗前（T0）、最后一次r-fMV治疗后1周（T1）和1个月（T2）进行。r-fMV治疗后，GA计算的大多数时空参数得到改善。此外，临床评估相关结果显示SM患者的生活质量有所提高。总之，r-fMV可改善受重度下肢痉挛影响且对常见口服抗痉挛药物无反应的MS患者的步态功能。
