Chiang Gloria C, Chang Eileen, Pandya Sneha, Kuceyeski Amy, Hu James, Isaacson Richard, Ganzer Christine, Schulman Aaron, Sobel Vivian, Vallabhajosula Shankar, Ravdin Lisa
Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
Department of Radiology, Division of Neuroradiology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, NY, United States.
J Neurol Sci. 2017 Jan 15;372:85-91. doi: 10.1016/j.jns.2016.11.040. Epub 2016 Nov 17.
To determine the effects of Type 2 diabetes (DM2) on levels of brain amyloidosis and cognition in a community-dwelling cohort of nondemented elderly individuals.
33 subjects (16 DM2, 17 nondiabetic) were prospectively recruited. Subjects underwent a PET scan using the amyloid tracer, Pittsburgh Compound B, and a neuropsychological evaluation. Associations between DM2, brain amyloidosis, and cognition were assessed using multivariate regressions, adjusting for age and APOE4 status.
DM2 subjects had lower global cognitive function (p=0.018), as measured by the Repeatable Battery for the Assessment of Neuropsychological Status. There was no difference in brain amyloidosis between groups (p=0.25).
Community-dwelling, nondemented individuals with DM2 had greater cognitive deficits, which do not appear to be mediated by brain amyloidosis. Further studies exploring potential mediators of these cognitive deficits should be performed.
确定2型糖尿病（DM2）对非痴呆老年社区居住队列中脑淀粉样变性水平和认知的影响。
前瞻性招募了33名受试者（16名DM2患者，17名非糖尿病患者）。受试者接受了使用淀粉样蛋白示踪剂匹兹堡化合物B的PET扫描和神经心理学评估。使用多元回归评估DM2、脑淀粉样变性和认知之间的关联，并对年龄和APOE4状态进行校正。
通过可重复神经心理状态评估量表测量，DM2受试者的整体认知功能较低（p=0.018）。两组之间的脑淀粉样变性没有差异（p=0.25）。
社区居住的非痴呆DM2个体存在更大的认知缺陷，这似乎不是由脑淀粉样变性介导的。应进行进一步研究以探索这些认知缺陷的潜在介导因素。
