Franzmeier Nicolai, Buerger Katharina, Teipel Stefan, Stern Yaakov, Dichgans Martin, Ewers Michael
Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University LMU, Munich, Germany.
Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; German Center for Neurodegenerative Diseases (DZNE, Rostock), Rostock, Germany.
Neurobiol Aging. 2017 Feb;50:152-162. doi: 10.1016/j.neurobiolaging.2016.11.013. Epub 2016 Dec 1.
Cognitive reserve (CR) shows protective effects on cognitive function in older adults. Here, we focused on the effects of CR at the functional network level. We assessed in patients with amnestic mild cognitive impairment (aMCI) whether higher CR moderates the association between low internetwork cross-talk on memory performance. In 2 independent aMCI samples (n = 76 and 93) and healthy controls (HC, n = 36), CR was assessed via years of education and intelligence (IQ). We focused on the anti-correlation between the dorsal attention network (DAN) and an anterior and posterior default mode network (DMN), assessed via sliding time window analysis of resting-state functional magnetic resonance imaging (fMRI). The DMN-DAN anti-correlation was numerically but not significantly lower in aMCI compared to HC. However, in aMCI, lower anterior DMN-DAN anti-correlation was associated with lower memory performance. This association was moderated by CR proxies, where the association between the internetwork anti-correlation and memory performance was alleviated at higher levels of education or IQ. In conclusion, lower DAN-DMN cross-talk is associated with lower memory in aMCI, where such effects are buffered by higher CR.
认知储备（CR）对老年人的认知功能具有保护作用。在此，我们聚焦于功能网络层面CR的影响。我们评估了遗忘型轻度认知障碍（aMCI）患者中，较高的CR是否会缓和记忆表现上低网络间串扰的关联。在两个独立的aMCI样本（n = 76和93）以及健康对照（HC，n = 36）中，通过受教育年限和智力（IQ）评估CR。我们通过静息态功能磁共振成像（fMRI）的滑动时间窗口分析，聚焦于背侧注意网络（DAN）与前后默认模式网络（DMN）之间的负相关。与HC相比，aMCI中DMN - DAN负相关在数值上较低，但无显著差异。然而，在aMCI中，较低的前侧DMN - DAN负相关与较低的记忆表现相关。这种关联受到CR指标的调节，在受教育程度或IQ较高水平时，网络间负相关与记忆表现之间的关联得到缓解。总之，较低的DAN - DMN串扰与aMCI中较低的记忆相关，其中这种影响会被较高的CR缓冲。
