Taşkıran Mehmet, Taşdemir Abdulkadir, Ayyıldız Nusret
Department of Biology, Faculty of Science, Erciyes University, 38039 Kayseri, Turkey.
Graduate School of Natural and Applied Sciences, Erciyes University, 38039 Kayseri, Turkey.
Brain Res Bull. 2017 Apr;130:42-46. doi: 10.1016/j.brainresbull.2016.12.010. Epub 2016 Dec 23.
The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy.
Male Wistar rats were used in all experiments (n=18). The seizure activity was triggered by penicillin (i.c.). Aceclofenac was injected intraperitoneally at doses of 10mg/kg and 20mg/kg.
Intraperitoneal administration of 10 and 20mg/kg aceclofenac doses, exhibited proconvulsant properties on seizure activity on rats. The mean spike frequency and amplitude of aceclofenac 10mg/kg were 41.89±2.12 spike/min and 0.619±0.094mV, respectively. The mean spike frequency and amplitude of aceclofenac 20mg/kg were 35.26±2.72 spike/min and 0.843±0.089mV, respectively.
The results indicated that not all of the COX-2 inhibitors may have anticonvulsant or proconvulsant features on patients with epilepsy susceptibility and must be used with great care. It was also suggested that not only cyclooxygenase metabolic pathway but also lipoxygenase pathway should be considered together in further detailed studies.
环氧化酶-2（COX-2）抑制剂对癫痫发作活动的影响存在争议。本研究的目的是确定醋氯芬酸对青霉素诱导的实验性癫痫的治疗后效果。
所有实验均使用雄性Wistar大鼠（n = 18）。癫痫发作活动由青霉素（脑内注射）触发。醋氯芬酸以10mg/kg和20mg/kg的剂量腹腔注射。
腹腔注射10mg/kg和20mg/kg剂量的醋氯芬酸对大鼠的癫痫发作活动表现出促惊厥特性。醋氯芬酸10mg/kg组的平均棘波频率和幅度分别为41.89±2.12次/分钟和0.619±0.094mV。醋氯芬酸20mg/kg组的平均棘波频率和幅度分别为35.26±2.72次/分钟和0.843±0.089mV。
结果表明，并非所有COX-2抑制剂对癫痫易感性患者都具有抗惊厥或促惊厥特性，必须谨慎使用。还建议在进一步的详细研究中，不仅应考虑环氧化酶代谢途径，还应同时考虑脂氧合酶途径。
