表观遗传学与常见眼科疾病
Epigenetics and Common Ophthalmic Diseases.
作者信息
Li Wendy, Liu Ji, Galvin Jennifer A
机构信息
Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
出版信息
Yale J Biol Med. 2016 Dec 23;89(4):597-600. eCollection 2016 Dec.
Abstract
The study of ocular diseases and epigenetic dysregulation is an emerging area of research. The knowledge from the epigenetic mechanisms of DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs regarding the pathogenesis of ocular diseases will be helpful for improved treatment modalities for our patients. In particular, we focus upon the how epigenetic regulatory mechanisms impact five common ocular diseases: age related macular degeneration, age-related cataract, pterygium, retinoblastoma, and uveal melanoma. Hence, the foundation of this research paves the way for future specific therapeutic targets to treat and prevent vision loss.
摘要
眼部疾病与表观遗传失调的研究是一个新兴的研究领域。从DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA的表观遗传机制中获得的关于眼部疾病发病机制的知识，将有助于改善我们对患者的治疗方式。特别是，我们关注表观遗传调控机制如何影响五种常见的眼部疾病：年龄相关性黄斑变性、年龄相关性白内障、翼状胬肉、视网膜母细胞瘤和葡萄膜黑色素瘤。因此，这项研究的基础为未来治疗和预防视力丧失的特定治疗靶点铺平了道路。
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