新生儿产前使用艾司西酞普兰与坏死性小肠结肠炎：一例报告
Antenatal Escitalopram Use and Necrotizing Enterocolitis in a Newborn: A Case Report.
作者信息
Jawale Nilima, Bhutada Alok, Rastogi Shantanu
机构信息
Division of Neonatology, Department of Pediatrics, Maimonides Medical Center, Brooklyn, New York.
出版信息
J Pediatr Pharmacol Ther. 2016 Nov-Dec;21(6):518-521. doi: 10.5863/1551-6776-21.6.518.
Abstract
The increased use of antidepressants during pregnancy has been associated with adverse effects in the newborn. We report a case of antenatal escitalopram use associated with necrotizing enterocolitis in a healthy term baby. We further discuss possible mechanisms that may explain this association. With increasing evidence of association of necrotizing enterocolitis with maternal exposure to antidepressants, more studies to find out causality and methods to predict babies at risk and their prudent management are needed.
摘要
孕期抗抑郁药使用的增加与新生儿的不良反应有关。我们报告了一例在足月健康婴儿中，产前使用艾司西酞普兰与坏死性小肠结肠炎相关的病例。我们进一步讨论了可能解释这种关联的机制。随着坏死性小肠结肠炎与母亲接触抗抑郁药之间关联的证据越来越多，需要更多的研究来找出因果关系以及预测高危婴儿的方法及其谨慎管理措施。
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本文引用的文献
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Pregnancy Complications Following Prenatal Exposure to SSRIs or Maternal Psychiatric Disorders: Results From Population-Based National Register Data.产前暴露于 SSRI 或母亲精神障碍后妊娠并发症：基于人群的国家登记数据结果。
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Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidence.发育期间暴露于选择性5-羟色胺再摄取抑制剂（SSRI）类抗抑郁药的持续神经行为影响：从分子到临床的证据
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