Mignon Charles, Rodriguez Aura Higuera, Palero Jonathan A, Varghese Babu, Jurna Martin
Department of Personal Care and Wellness, Philips Research, 5656 AE, Eindhoven, The Netherlands.
Biomed Opt Express. 2016 Nov 7;7(12):4974-4981. doi: 10.1364/BOE.7.004974. eCollection 2016 Dec 1.
Fractional photothermolysis uses lasers to generate a pattern of microscopic columnar thermal lesions within the skin stimulating collagen remodeling. In this paper we investigate the use of Bessel beams as an alternative to conventional Gaussian beams in creating laser photothermal lesions of different aspect ratios in skin. We show for the first time the improved photothermal lesion depth-to-diameter aspect ratio using Bessel beams in human skin as well as in numerical simulations using electric field Monte Carlo photon transport, finite difference methods and Arrhenius model. Bessel beams allow the creation of deep and narrow thermal lesions necessary for improved efficacy in fractional photothermolysis.
分段光热解疗法利用激光在皮肤内生成微小柱状热损伤模式，刺激胶原蛋白重塑。在本文中，我们研究了使用贝塞尔光束替代传统高斯光束，在皮肤中创建不同纵横比的激光光热损伤。我们首次展示了在人体皮肤以及使用电场蒙特卡洛光子传输、有限差分方法和阿伦尼乌斯模型的数值模拟中，使用贝塞尔光束可提高光热损伤的深度与直径纵横比。贝塞尔光束能够创建深度且狭窄的热损伤，这对于提高分段光热解疗法的疗效是必要的。
