血管紧张素-（1-7）在人内皮细胞中调控的其他细胞内蛋白质和信号通路。
Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells.
作者信息
Meinert Christian, Kohse Franziska, Böhme Ilka, Gembardt Florian, Tetzner Anja, Wieland Thomas, Greenberg Barry, Walther Thomas
机构信息
Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
出版信息
Data Brief. 2016 Dec 8;10:354-363. doi: 10.1016/j.dib.2016.12.004. eCollection 2017 Feb.
In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1-7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1-7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1-7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.
2016年，迈纳特等人（doi: 10.1016/j.jprot.2015.09.020）发表了人脐静脉内皮细胞（HUVEC）中由七肽血管紧张素（Ang）-(1-7)调控的蛋白质阵列中的首批25种蛋白质，以及在不同时间点的首批10种细胞内信号级联反应。这篇支持性数据文章展示了在1小时、3小时、6小时和9小时时间点，Ang-(1-7)在人内皮细胞中刺激的更多蛋白质和信号通路。用Ang-(1-7)刺激HUVEC，并通过抗体微阵列鉴定调控的蛋白质。使用生物信息学软件IPA将调控的蛋白质与代谢途径进行关联。
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