帕金森病中的 5-羟色胺转运体：正电子发射断层扫描研究的荟萃分析。
Serotonin transporter in Parkinson's disease: A meta-analysis of positron emission tomography studies.
机构信息
Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
出版信息
Ann Neurol. 2017 Feb;81(2):171-180. doi: 10.1002/ana.24859.
Positron emission tomography (PET) is a powerful analytical tool for in vivo molecular imaging of the human brain. Over the past years, a number of PET studies imaging the serotonin transporter (SERT) have been used and provided evidence for the key role of serotonergic pathology in patients with Parkinson's disease (PD). Here, we review the role of SERT in the development of motor and nonmotor complications in patients with PD, and we performed a meta-analysis to identify the patterns of SERT pathology and the relevance to symptoms. Consistent SERT pathology in raphe nuclei, striatum, thalamus, and hypothalamus and associations with aging, PD progression, development of dyskinesias, and cognitive decline were observed. Ann Neurol 2017;81:171-180.
正电子发射断层扫描（PET）是一种强大的分析工具，可用于对人脑进行体内分子成像。在过去的几年中，许多研究 SERT 的 PET 研究已经被用于为帕金森病（PD）患者的 5-羟色胺能病理学的关键作用提供证据。在这里，我们综述了 SERT 在 PD 患者运动和非运动并发症发展中的作用，并且我们进行了荟萃分析以确定 SERT 病理学的模式及其与症状的相关性。观察到中缝核、纹状体、丘脑和下丘脑的 SERT 病理学一致，并与衰老、PD 进展、运动障碍的发展和认知能力下降有关。Ann Neurol 2017;81:171-180.
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