Durá Trave T, Moya Benavent M, Buades Esplá A
Hospital Provincial, Facultad de Medicina, Departamento de Pediatría, Universidad de Alicante.
An Esp Pediatr. 1989 Jul;31(1):39-42.
A single oral dose of 0.15 mg/m2 of clonidine was given to twenty children and adolescents (range 1.6 to 17.4 years) with short stature (height standard deviation score -3.3 +/- 1.1). In 18 (90%) tests the plasma growth hormone response was positive (13.5 +/- 7 ng/ml) without false-negatives. 16 (80%) were drowsy, lasting for 3-4 hours. The systolic blood pressure decreased from 99.6 +/- 13 mmHg (basal) to 81 +/- 13.9 and 85.8 +/- 11.8 (p less than 0.05), after 180 and 240 minutes of clonidine administration. The cardiac frequency decreased from 92 +/- 18 to 74 +/- 14 beat/minute (p less than 0.05). A positive linear correlation (p less than 0.05) was found between peak serum growth hormone concentration and peak systolic hypotension (r = 0.707). The great sensitivity of the clonidine test is confirmed. The side-effects observed suggest that it is necessary to control blood pressure during the 5 hours following the oral administration of clonidine.
对20名身材矮小（身高标准差评分-3.3±1.1）的儿童和青少年（年龄范围1.6至17.4岁）口服单次剂量0.15mg/m²可乐定。在18次（90%）检测中，血浆生长激素反应呈阳性（13.5±7ng/ml），无假阴性。16人（80%）出现嗜睡，持续3 - 4小时。服用可乐定180分钟和240分钟后，收缩压从99.6±13mmHg（基础值）降至81±13.9和85.8±11.8（p<0.05）。心率从92±18降至74±14次/分钟（p<0.05）。血清生长激素浓度峰值与收缩期低血压峰值之间存在正线性相关性（p<0.05）（r = 0.707）。可乐定试验的高敏感性得到证实。观察到的副作用表明，口服可乐定后5小时内有必要监测血压。
