通过Gβγ对核内体甲状旁腺激素受体信号传导的β-肾上腺素能受体调控
β-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.
作者信息
Jean-Alphonse Frédéric G, Wehbi Vanessa L, Chen Jingming, Noda Masaki, Taboas Juan M, Xiao Kunhong, Vilardaga Jean-Pierre
机构信息
Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Department of Biomedical Engineering, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
出版信息
Nat Chem Biol. 2017 Mar;13(3):259-261. doi: 10.1038/nchembio.2267. Epub 2016 Dec 26.
Abstract
Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the β-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein Gβγ subunits on adenylate cyclase type 2.
摘要
细胞在其表面表达多种G蛋白偶联受体（GPCR），将细胞外的激素和化学信号同时传递到细胞内。因此，需要全面了解由不同GPCR诱导的整合信号反应的潜在机制。在这里，我们发现，诱导短暂cAMP反应的β-肾上腺素能受体，通过G蛋白Gβγ亚基对2型腺苷酸环化酶的刺激作用，促进甲状旁腺激素（PTH）受体信号传导中的内体cAMP产生，从而延长核cAMP和蛋白激酶A（PKA）的激活。
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