Anzai Ryosuke, Takami Taku, Uchida Yusuke, Murakami Yoshihiko
Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Japan.
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:325-331. doi: 10.1016/j.msec.2016.11.090. Epub 2016 Nov 24.
In the present paper, we clarify the effects that the composition of three types of sheets-the PCL sheet, the PCL-BC (PCL-block copolymer composite) sheet, and the PCL-PM (PCL-polymeric micelle composite) sheet-can have on (1) the sheets' inner structure, (2) the dispersity of hydrophilic compounds in the sheets, (3) the sheets' mechanical properties, and (4) the sheets' degradability. Our results show that (1) the PCL-PM sheet can disperse hydrophilic compounds uniformly, (2) the molecular state (free or micellar) of a co-existing compound (PEG-b-PCL block copolymers) affects the strength and the inner structures of the sheets, whereas the presence of a co-existing compound affects the flexibility of the sheets, and (3) according to our degradation experiment, hard-to-handle PCL having extremely low hydrolysis could serve as materials with a controllable surface morphology by the effective use of co-existing compounds. The results obtained in this paper show that the PCL-CM sheet, with its uniformly dispersed polymeric micelles providing hydrophilic spaces, could be an effective biomaterial platform for incorporating hydrophilic polymers.
在本文中，我们阐明了三种类型的片材——聚己内酯（PCL）片材、聚己内酯-嵌段共聚物复合材料（PCL-BC）片材和聚己内酯-聚合物胶束复合材料（PCL-PM）片材的组成对以下方面的影响：（1）片材的内部结构；（2）亲水性化合物在片材中的分散性；（3）片材的机械性能；（4）片材的降解性。我们的结果表明：（1）PCL-PM片材能够使亲水性化合物均匀分散；（2）共存化合物（聚乙二醇-b-聚己内酯嵌段共聚物）的分子状态（游离或胶束状态）会影响片材的强度和内部结构，而共存化合物的存在会影响片材的柔韧性；（3）根据我们的降解实验，水解程度极低、难以处理的PCL通过有效利用共存化合物可作为具有可控表面形态的材料。本文获得的结果表明，具有均匀分散的聚合物胶束并提供亲水性空间的PCL-CM片材可能是用于掺入亲水性聚合物的有效生物材料平台。
