Xia Kada, Pan Hui, Wang Taolei, Ma Shangjun, Niu Junchao, Xiang Zhen, Song Yiming, Yang Huawei, Tang Xiaoshan, Lu Wei
School of Materials Science and Engineering, Shanghai Key Laboratory of D&A for Metal-Functional Materials, Tongji University, Shanghai 201804, China.
Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:676-681. doi: 10.1016/j.msec.2016.11.132. Epub 2016 Dec 3.
Magnesium and its alloys have attracted much attention as metallic biodegradable implants for their excellent biocompatibility and mechanical properties. However, magnesium has a poor corrosion resistance, causing its rapid degrading in vivo via an electrochemical reaction, which has become a major obstacle to their applications in implants. In this work, CaP coating was successfully coated on the ZK60 magnesium alloys by a simple hydrothermal deposition method. The mechanisms of the hydrothermal reactions of CaP coatings on Mg substrate are described in details. The effect of Ca/P ratio in the hydrothermal solution on the phase composition, microstructure and biodegradation properties of CaP coatings on ZK60 alloys was investigated by varying the Ca/P ratio from 0.83 to 4.18. The morphology of the CaP coating changed significantly with the Ca/P ratio. Biodegradation behavior of the CaP coating magnesium was characterized by anodic polarization and immersion tests in a simulated body fluid. It is revealed that the corrosion resistance of ZK60 magnesium alloy was greatly improved with the biomimetic CaP coatings, and the ZK60 alloy with CaP coating deposited at Ca/P ratio of 1.67 has the best corrosion resistance, which indicates that the CaP coatings are promising for improving the biodegradation properties of Mg-based orthopedic implants and devices.
镁及其合金因其优异的生物相容性和机械性能，作为金属可生物降解植入物备受关注。然而，镁的耐腐蚀性较差，导致其在体内通过电化学反应快速降解，这已成为其在植入物应用中的主要障碍。在这项工作中，通过简单的水热沉积法成功地在ZK60镁合金上涂覆了CaP涂层。详细描述了Mg基体上CaP涂层的水热反应机理。通过将水热溶液中的Ca/P比从0.83变化到4.18，研究了其对ZK60合金上CaP涂层的相组成、微观结构和生物降解性能的影响。CaP涂层的形貌随Ca/P比发生了显著变化。通过阳极极化和在模拟体液中的浸泡试验对CaP涂层镁的生物降解行为进行了表征。结果表明，仿生CaP涂层大大提高了ZK60镁合金的耐腐蚀性，Ca/P比为1.67时沉积的CaP涂层的ZK60合金具有最佳的耐腐蚀性，这表明CaP涂层有望改善镁基金属骨科植入物和器械的生物降解性能。
