Yamada Shin-Ichi, Kurita Hiroshi, Tomioka Takahiro, Ohta Ryousuke, Yoshimura Nobuhiko, Nishimaki Fumihiro, Koyama Yoshihito, Kondo Eiji, Kamata Takahiro
Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto 390-8621, Japan.
Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto 390-8621, Japan.
Oral Oncol. 2017 Jan;64:22-26. doi: 10.1016/j.oraloncology.2016.11.014. Epub 2016 Dec 1.
Healthy life expectancy, an extension of the concept of life expectancy, is a summary measure of population health that takes into account the mortality and morbidity of a population. The aim of the present study was to retrospectively analyze the self-reliance survival times of oral squamous cell carcinoma (OSCC) patients.
One hundred and twelve patients aged 75years or older with primary OSCC were included and examined at Shinshu University Hospital. To investigate healthy life expectancy, OSCC patients older than 75years were divided into 3 groups: 75-79, 80-84, and older than 85years. The Kaplan-Meier method was used to estimate the median times of healthy life expectancy. The Log-rank test was used to test significant differences between actual curves.
The median self-reliance survival times of patients aged 75-79, 80-84, and older than 85years were 5.7, 1.6, and 1.4years, respectively. Most patients with early stage cancers underwent curative treatments and showed a health expectancy of more than 5years. In patients with advanced cancers, health expectancy was poor (less than one year), except among patients aged 75-79years who underwent standard treatments.
It seems that in patients with advanced cancers, health expectancy was poor (less than 1year), except among patients aged 75-79years who underwent standard treatments. In elderly patients, healthy life expectancy (self-reliance survival time) may be one of the measures of patient prognosis as well as overall survival times.
健康预期寿命是预期寿命概念的延伸，是一种考虑了人群死亡率和发病率的人群健康综合指标。本研究的目的是回顾性分析口腔鳞状细胞癌（OSCC）患者的自理生存时间。
纳入112例年龄在75岁及以上的原发性OSCC患者，并在信州大学医院进行检查。为了研究健康预期寿命，将75岁以上的OSCC患者分为3组：75 - 79岁、80 - 84岁和85岁以上。采用Kaplan - Meier方法估计健康预期寿命的中位数时间。采用对数秩检验来检验实际曲线之间的显著差异。
75 - 79岁、80 - 84岁和85岁以上患者的自理生存时间中位数分别为5.7年、1.6年和1.4年。大多数早期癌症患者接受了根治性治疗，健康预期寿命超过5年。在晚期癌症患者中，健康预期寿命较差（少于1年），但75 - 79岁接受标准治疗的患者除外。
似乎在晚期癌症患者中，健康预期寿命较差（少于1年），但75 - 79岁接受标准治疗的患者除外。在老年患者中，健康预期寿命（自理生存时间）可能是患者预后以及总生存时间的衡量指标之一。
