毒扁豆碱治疗进行性核上性麻痹。
Physostigmine treatment of progressive supranuclear palsy.
作者信息
Litvan I, Gomez C, Atack J R, Gillespie M, Kask A M, Mouradian M M, Chase T N
机构信息
Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
出版信息
Ann Neurol. 1989 Sep;26(3):404-7. doi: 10.1002/ana.410260318.
Cognitive and extrapyramidal effects of cholinomimetic therapy were evaluated in 8 patients with progressive supranuclear palsy. Each was randomized to a 10-day double-blind crossover trial of physostigmine and placebo. Physostigmine treatment was associated with marginal and inconsistent changes in long-term memory, suggesting that cholinergic therapy alone is insufficient to restore cognitive function. Motor scores remained unchanged.
对8例进行性核上性麻痹患者评估了拟胆碱疗法的认知和锥体外系效应。每位患者均被随机分配至毒扁豆碱和安慰剂的10天双盲交叉试验。毒扁豆碱治疗与长期记忆的轻微且不一致的变化相关，提示单纯胆碱能疗法不足以恢复认知功能。运动评分保持不变。
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