Kwon Min Jung, Ryu Soo Hyung, Jo Soo Yeon, Kwak Chul Hoon, Yoon Won Jae, Moon Jeong Seop, Lee Hye Kyung
Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Department of Pathology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2016 Dec 25;68(6):321-325. doi: 10.4166/kjg.2016.68.6.321.
Oral metastatic tumor, which is uncommon and represents less than 1% of malignant oral neoplasms, usually arises from a primary mucosal or cutaneous cancer located in the head and neck regions. Metastasis of hepatocellular carcinoma (HCC) to the oral cavity, especially to gingiva, is extremely rare. A 50-year-old man, who was a chronic alcoholic and hepatitis B virus carrier, presented with abdominal distension and weight loss for the past 3 months. Three-phased contrast-enhanced abdominal CT revealed numerous conglomerated masses in the liver, suggesting huge HCCs arising in the background of liver cirrhosis with a large amount of ascites. He complained of recurrent profuse bleeding from the left upper gingival mass. A facial CT revealed an oral cavity mass destructing the left maxillary alveolar process and hard palate, which was diagnosed as metastatic HCC by an incisional biopsy. Herein, we report a case of metastatic HCC to the gingiva.
口腔转移性肿瘤并不常见,占口腔恶性肿瘤的比例不到1%,通常源于头颈部的原发性黏膜或皮肤癌。肝细胞癌(HCC)转移至口腔,尤其是牙龈,极为罕见。一名50岁男性,有长期酗酒史且为乙肝病毒携带者,在过去3个月出现腹胀和体重减轻。腹部三期增强CT显示肝脏有大量融合性肿块,提示在肝硬化背景下出现巨大HCC,并伴有大量腹水。他主诉左上牙龈肿物反复大量出血。面部CT显示口腔肿物破坏了左上颌牙槽突和硬腭,经切开活检诊断为转移性HCC。在此,我们报告一例牙龈转移性HCC病例。