孕早期非整倍体筛查试验血清分析物与胎盘植入的关系。
Relationship between first trimester aneuploidy screening test serum analytes and placenta accreta.
作者信息
Büke Barış, Akkaya Hatice, Demir Sibel, Sağol Sermet, Şimşek Deniz, Başol Güneş, Barutçuoğlu Burcu
机构信息
a Department of Gynecology and Obstetrics, Kayseri Training and Research Hospital , Kayseri , Turkey.
b Department of Gynecology and Obstetrics , Aksaray Ortaköy State Hospital , Aksaray , Turkey.
出版信息
J Matern Fetal Neonatal Med. 2018 Jan;31(1):59-62. doi: 10.1080/14767058.2016.1275546. Epub 2017 Jan 17.
OBJECTIVE
The aim of this study is to determine whether there is a relationship between first trimester serum pregnancy-associated plasma protein A (PAPP-A) and free beta human chorionic gonadotropin (fβhCG) MoM values and placenta accreta in women who had placenta previa.
STUDY DESIGN
A total of 88 patients with placenta previa who had first trimester aneuploidy screening test results were enrolled in the study. Nineteen of these patients were also diagnosed with placenta accreta. As probable markers of excessive placental invasion, serum PAPP-A and fβhCG MoM values were compared in two groups with and without placenta accreta.
RESULTS
Patients with placenta accreta had higher statistically significant serum PAPP-A (1.20 versus 0.865, respectively, p = 0.045) and fβhCG MoM (1.42 versus 0.93, respectively, p = 0.042) values than patients without accreta.
CONCLUSIONS
Higher first trimester serum PAPP-A and fβhCG MoM values seem to be associated with placenta accreta in women with placenta previa. Further studies are needed to use these promising additional tools for early detection of placenta accreta.
目的
本研究旨在确定前置胎盘女性孕早期血清妊娠相关血浆蛋白A（PAPP-A）和游离β人绒毛膜促性腺激素（fβhCG）的中位数倍数（MoM）值与胎盘植入之间是否存在关联。
研究设计
共有88例有孕早期非整倍体筛查结果的前置胎盘患者纳入本研究。其中19例患者还被诊断为胎盘植入。作为胎盘过度侵入的可能标志物，对有胎盘植入和无胎盘植入的两组患者的血清PAPP-A和fβhCG MoM值进行了比较。
结果
有胎盘植入的患者血清PAPP-A值（分别为1.20和0.865，p = 0.045）和fβhCG MoM值（分别为1.42和0.93，p = 0.042）在统计学上显著高于无胎盘植入的患者。
结论
孕早期血清PAPP-A和fβhCG MoM值较高似乎与前置胎盘女性的胎盘植入有关。需要进一步研究以利用这些有前景的额外工具来早期检测胎盘植入。
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