Teichmann A T, Arendt P, Osmers R, Speer C P
Frauenklinik Universität, Göttingen.
Arch Gynecol Obstet. 1989;245(1-4):824-7. doi: 10.1007/BF02417577.
Serum concentrations of leucocytes, C-reactive protein (CRP) and elastase-alpha 1-proteinase inhibitor (E alpha 1 PI) have been determined in 85 women during pregnancy and after birth to assess their diagnostic value in case of amniotic infections (AI). In ten patients clinically diagnosed AI could be confirmed by histopathological examination, three patients who fulfilled the clinical criteria showed no histological signs of infection. E alpha 1 PI-levels were found to be elevated to over 200 meg/l in six patients with clinical and histological infection and remained below this value in all other cases whereas leucocyte- and CRP concentrations raised in five out of these eight women but also showed false positive values in patients without AI. The application of betamethasone led to a marked elevation of leucocyte concentration. CRP levels were raised substantially after birth, whereas E alpha 1 PI remained unchanged. It is suggested that all three parameters should be taken into consideration to increase diagnostic reliability in case of suspected amniotic infections.
已对85名女性在孕期及产后测定了血清白细胞、C反应蛋白（CRP）和弹性蛋白酶-α1-蛋白酶抑制剂（Eα1PI）的浓度，以评估它们在羊水感染（AI）情况下的诊断价值。10例临床诊断为AI的患者经组织病理学检查得以确诊，3例符合临床标准的患者未显示出感染的组织学迹象。在6例临床和组织学均诊断为感染的患者中，Eα1PI水平升高至超过200mg/l，在所有其他病例中均低于该值，而这8名女性中有5名白细胞和CRP浓度升高，但在无AI的患者中也出现了假阳性值。应用倍他米松导致白细胞浓度显著升高。出生后CRP水平大幅升高，而Eα1PI保持不变。建议在怀疑羊水感染时应考虑所有这三个参数，以提高诊断的可靠性。
