Liu S, Wang Y, Fan X, Ma J, Qiu X, Jiang T
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Clin Radiol. 2017 May;72(5):426.e1-426.e6. doi: 10.1016/j.crad.2016.11.013. Epub 2016 Dec 24.
To investigate the prognostic role of subventricular zone (SVZ) involvement in anaplastic glioma.
The magnetic resonance imaging and clinical data of 160 patients with histopathologically confirmed anaplastic glioma treated at Beijing Tiantan hospital were retrospectively reviewed. The relationship between survival and the region of the SVZ involved was determined via univariate and multivariate analysis.
In the univariate analysis, SVZ involvement significantly correlated with progression-free survival (p=0.021) and overall survival (p<0.001). Multivariate analysis showed that SVZ involvement was an independent prognostic factor for unfavourable survival (p=0.016 for overall survival), as was the involvement of the occipital horn of the SVZ (p<0.001 for progression-free survival, and p=0.016 for overall survival).
The current study shows that SVZ involvement is a valid prognostic indicator in anaplastic glioma. It is associated with worse prognosis in patients with anaplastic gliomas, particularly those with tumours invading the occipital horn of the SVZ.
探讨室管膜下区（SVZ）受累在间变性胶质瘤中的预后作用。
回顾性分析北京天坛医院收治的160例经组织病理学证实的间变性胶质瘤患者的磁共振成像和临床资料。通过单因素和多因素分析确定生存与SVZ受累区域之间的关系。
单因素分析显示，SVZ受累与无进展生存期（p=0.021）和总生存期（p<0.001）显著相关。多因素分析表明，SVZ受累是生存不良的独立预后因素（总生存期p=0.016），SVZ枕角受累也是如此（无进展生存期p<0.001，总生存期p=0.016）。
本研究表明，SVZ受累是间变性胶质瘤的有效预后指标。它与间变性胶质瘤患者的预后较差有关，尤其是那些肿瘤侵犯SVZ枕角的患者。
