Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China; Shanghai Diabetes Institute, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Clin Nutr. 2018 Feb;37(1):223-228. doi: 10.1016/j.clnu.2016.12.010. Epub 2016 Dec 18.
BACKGROUND & AIMS: Recent findings raise the possibility that fibroblast growth factor (FGF) 23 may be related with fat contents and distribution. The present study aimed to elucidate the associations of serum FGF23 levels with the fat contents and distribution.
A total of 1599 normoglycemic individuals with preserved kidney function were enrolled. Serum levels of intact FGF23 were detected using a sandwich enzyme-linked immunosorbent assay. Overweight/obesity was defined by a body mass index of ≥25.0 kg/m. Visceral fat area (VFA) was assessed by magnetic resonance imaging, and abdominal obesity was defined as VFA ≥80 cm.
Among the study population of 597 men, 411 premenopausal women, and 591 postmenopausal women, serum FGF23 levels were significantly increased in participants with overweight/obesity and abdominal obesity, respectively (both P < 0.001). Each one-unit increase in VFA was associated with a 0.028-pg/mL increase in serum FGF23 levels in men (P = 0.001) and a 0.051-pg/mL increase in serum FGF23 levels in postmenopausal women (P < 0.001). Whether in the presence of overweight/obesity or not, the presence of abdominal obesity was independently associated with the increase in serum FGF23 levels in men and postmenopausal women (all P < 0.05).
Serum FGF23 levels are elevated in obese individuals, especially those with abdominal obesity. The independent associations between the presence of abdominal obesity and the increase in serum FGF23 levels in specific groups suggest that serum FGF23 levels may indicate the risk of metabolic and cardiovascular disease in men and postmenopausal women.
最近的研究结果表明，成纤维细胞生长因子 23（FGF23）可能与脂肪含量和分布有关。本研究旨在阐明血清 FGF23 水平与脂肪含量和分布的关系。
共纳入 1599 例肾功能正常的血糖正常个体。采用夹心酶联免疫吸附法检测血清中完整 FGF23 的水平。超重/肥胖定义为体质指数（BMI）≥25.0 kg/m²。通过磁共振成像评估内脏脂肪面积（VFA），并将腹型肥胖定义为 VFA≥80 cm²。
在 597 名男性、411 名绝经前女性和 591 名绝经后女性的研究人群中，超重/肥胖和腹型肥胖患者的血清 FGF23 水平均显著升高（均 P<0.001）。男性 VFA 每增加一个单位，血清 FGF23 水平增加 0.028 pg/mL（P=0.001），绝经后女性血清 FGF23 水平增加 0.051 pg/mL（P<0.001）。无论是否存在超重/肥胖，腹型肥胖的存在与男性和绝经后女性血清 FGF23 水平的升高均独立相关（均 P<0.05）。
肥胖个体，尤其是腹型肥胖个体，血清 FGF23 水平升高。特定人群中腹型肥胖的存在与血清 FGF23 水平升高之间的独立相关性表明，血清 FGF23 水平可能预示着男性和绝经后女性发生代谢和心血管疾病的风险。
