支气管肺泡灌洗、支气管刷检和细针穿刺抽吸活检在诊断肺部恶性肿瘤中的对比研究
Comparative study of bronchoalveolar lavage, bronchial brushing, and FNAC in diagnosing malignant neoplasms of lungs.
作者信息
Tomar Vijeta, Vijay N, Nuwal P, Dixit R
机构信息
Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.
Department of Pathology, KEM Hospital, Pune, Maharashtra, India.
出版信息
J Cytol. 2016 Oct-Dec;33(4):210-213. doi: 10.4103/0970-9371.190448.
BACKGROUND
Lung cancer is the leading cause of death in developed countries and is increasing at alarming rates in developing countries. Cytological techniques such as bronchoalveolar lavage (BAL), bronchial brushing (BB), and fine needle aspiration cytology (FNAC) can aid in the early diagnosis of lung malignancies.
MATERIALS AND METHODS
A total of 67 cases, suspected of lung cancer between January 2010 and December 2012, were selected where samples of BAL, BB, FNAC, as well as biopsy were obtained and processed according to the standard procedures of cytology and histology. The aim of this study was to compare the diagnostic efficacy of the three modalities, i.e., BAL, BB, and FNAC in diagnosing malignant neoplasms of the lung. Biopsy was considered to be the gold standard diagnostic test.
RESULTS
Sensitivity of BAL, BB, and FNAC was found to be 47.61, 65.07, and 88.88%, respectively, whereas specificity of BAL, BB, and FNAC was 75, 75, and 100%, respectively.
CONCLUSIONS
FNAC is the best technique among the three for the diagnosis of lung cancers.
背景
肺癌是发达国家的主要死因，且在发展中国家正以惊人的速度增长。支气管肺泡灌洗（BAL）、支气管刷检（BB）和细针穿刺细胞学检查（FNAC）等细胞学技术有助于肺癌的早期诊断。
材料与方法
选取2010年1月至2012年12月期间共67例疑似肺癌的病例，获取BAL、BB、FNAC样本以及活检样本，并按照细胞学和组织学的标准程序进行处理。本研究的目的是比较BAL、BB和FNAC这三种方法在诊断肺恶性肿瘤方面的诊断效能。活检被视为金标准诊断测试。
结果
发现BAL、BB和FNAC的敏感性分别为47.61%、65.07%和88.88%，而BAL、BB和FNAC的特异性分别为75%、75%和100%。
结论
在这三种方法中，FNAC是诊断肺癌的最佳技术。
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