Milev Ivan, Zafirovska Planinka, Zimbakov Zan, Idrizi Shpend, Ampova-Sokolov Vilma, Gorgieva Emilija, Ilievska Liljana, Tosheski Goce, Hristov Nikola, Georgievska-Ismail Ljubica, Anguseva Tanja, Mitrev Zan
Special Hospital for Surgical Diseases "Filip Vtori", Cardiology, Skopje, Republic of Macedonia.
University Clinic of Cardiology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Open Access Maced J Med Sci. 2016 Dec 15;4(4):613-618. doi: 10.3889/oamjms.2016.113. Epub 2016 Oct 5.
Percutaneous transcatheter closure (PTC) of patent foramen ovale (PFO) is implicated in cryptogenic stroke, transitional ischemic attack (TIA) and treatment of a migraine.
Our goal was to present our experience in the interventional treatment of PFO, as well as to evaluate the short and mid-term results in patients with closed PFO.
Transcatheter closure of PFO was performed in 52 patients (67.3% women, mean age 40.7 ± 11.7 years). Patients were interviewed for subjective grading of the intensity of headaches before and after the PFO closure.
During 2 years of follow-up, there was no incidence of new stroke, TIA and/or syncope. Follow-up TCD performed in 35 patients showed complete PFO closure in 20 patients (57.1%). Out of 35 patients, 22 (62.9%) reported having a migraine before the procedure with an intensity of headaches at 8.1 ± 1.9 on a scale from 1 to 10. During 2 years of follow-up, symptoms of a migraine disappeared in 4 (18.2%) and the remaining 18 patients reported the significant decrease in intensity 4.8 ± 2.04 (p = 0.0001). In addition, following PFO closure the incidence of the headaches decreased significantly (p = 0.0001).
Percutaneous transcatheter closure of PFO is a safe and effective procedure showing mid-term relief of neurological symptoms in patients as well as significant reduction of migraine symptoms.
卵圆孔未闭（PFO）的经皮导管封堵术（PTC）与不明原因卒中、短暂性脑缺血发作（TIA）及偏头痛治疗有关。
我们的目标是介绍我们在PFO介入治疗方面的经验，并评估PFO封堵患者的短期和中期结果。
对52例患者（女性占67.3%，平均年龄40.7±11.7岁）进行了PFO经导管封堵术。在PFO封堵前后对患者进行访谈，以主观分级头痛强度。
在2年的随访期间，未发生新的卒中、TIA和/或晕厥。对35例患者进行的随访经颅多普勒检查显示，20例患者（57.1%）PFO完全封堵。在35例患者中，22例（62.9%）在手术前报告有偏头痛，头痛强度在1至10分的量表上为8.1±1.9。在2年的随访期间，4例（18.2%）偏头痛症状消失，其余18例患者报告头痛强度显著降低至4.8±2.04（p = 0.0001）。此外，PFO封堵后头痛发生率显著降低（p = 0.0001）。
PFO经皮导管封堵术是一种安全有效的手术，可使患者神经症状得到中期缓解，并显著减轻偏头痛症状。
