Epstein Nancy E
Department of Neuroscience, Winthrop Neuroscience, Winthrop University Hospital, Mineola, New York, USA.
Surg Neurol Int. 2016 Nov 21;7(Suppl 38):S901-S904. doi: 10.4103/2152-7806.194515. eCollection 2016.
Establishing a clear treatment paradigm for octogenarians with type II odontoid fractures in hampered by a literature replete with level III articles.
In the study by Graffeo ., the authors evaluated 111 patients over the age of 79 (average age: 87) with type II odontoid fractures undergoing nonoperative (94 patients) vs. operative intervention (17 total; 15 posterior and 2 anterior). They studied multiple variables and utilized several scales [abbreviated injury scale (AIS), injury severity score (ISS), and the Glasgow coma scale (GCS)] to determine the outcomes of nonoperative vs. operative management.
Graffeo . concluded that there were no significant differences between nonoperative and operative management for type II odontoid fractures in octogenarians. They found similar frequencies of additional cervical fractures, mechanisms of injury, GCS of 8 or under, AIS/ISS scores, and disposition to "nonhome" facilities. Furthermore, both appeared to have increased mortality rates at 1-year post injury; 13% during hospitalization, 26% within the first post-injury month, and 41% at 1 year.
In the editorial by Falavigna, his major criticism of Graffeo's article was the marked disparity in the number of patients in the operative (17 patients) vs. the nonoperative group (94 patients), making it difficult to accept any conclusions as "significant". He further noted that few prior studies provided level I evidence, and that most, like this one, were level III analyses that did not "significantly" advance our knowledge as to whether to treat octogenarians with type II odontoid fractures operatively vs. nonoperatively.
由于充斥着大量三级文献,为患有Ⅱ型齿状突骨折的八旬老人建立明确的治疗模式受到阻碍。
在格拉菲奥等人的研究中,作者评估了111例79岁以上(平均年龄:87岁)的Ⅱ型齿状突骨折患者,其中94例接受非手术治疗,17例接受手术干预(15例后路手术,2例前路手术)。他们研究了多个变量,并使用了几种量表[简明损伤量表(AIS)、损伤严重程度评分(ISS)和格拉斯哥昏迷量表(GCS)]来确定非手术与手术治疗的结果。
格拉菲奥等人得出结论,八旬老人Ⅱ型齿状突骨折的非手术治疗与手术治疗之间没有显著差异。他们发现额外颈椎骨折的发生率、损伤机制、GCS评分在8分及以下、AIS/ISS评分以及入住“非家庭”机构的情况相似。此外,两者在受伤后1年的死亡率似乎都有所上升;住院期间为13%,受伤后第一个月内为26%,1年后为41%。
在法拉维尼亚的社论中,他对格拉菲奥文章的主要批评是手术组(17例患者)与非手术组(94例患者)的患者数量存在显著差异,这使得难以接受任何“显著”的结论。他进一步指出,很少有先前的研究提供一级证据,而且大多数研究,如本研究,都是三级分析,并没有“显著”推进我们对于八旬老人Ⅱ型齿状突骨折是进行手术治疗还是非手术治疗的认识。